{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:56:31Z","timestamp":1787068591370,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Oesophagogastric junction and gastric adenocarcinoma (OGA) are associated with high mortality rates, with 5\u2010year survival rates below 50% in the curative setting. This study evaluates the efficacy of adjuvant chemotherapy (a chemotherapy regimen consisting of docetaxel, oxaliplatin, leucovorin and 5\u2010fluorouracil [FLOT]) in patients with low tumour regression grades (TRG) following neoadjuvant FLOT (&gt;10% viable tumour cells in surgical specimen, TRG 2\/3 analogue Becker's classification). Data from all patients who had undergone \u22653\u2009cycles of neoadjuvant FLOT with R0 resection and TRG 2\/3 in surgical specimen, diagnosed between 2017 and 2020 at the University of Cologne (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009134), were analyzed. Patients were categorised into three groups based on the administration of postoperative FLOT: \u2018FLOT complete\u2019 (four cycles), \u2018FLOT incomplete\u2019 (one to three cycles) and \u2018no FLOT\u2019 (0\u2009cycles). Progression\u2010free survival (PFS) and overall survival (OS) were compared. There is a statistically significant PFS advantage for the \u2018FLOT complete\u2019 group compared to \u2018no FLOT\u2019 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.028) in the total patient cohort and a tendency for an OS benefit. In the subgroup of patients with lymph node metastasis in surgical specimen (ypN+ cohort,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200991), the PFS advantage of \u2018FLOT complete\u2019 was diminished and statistically no longer significant, and there is no OS benefit for these patients. However, multivariate analysis confirmed a significant PFS benefit for \u2018FLOT complete\u2019 both in the total cohort (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.011) and in ypN+ patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.018). These findings suggest that full adjuvant FLOT is beneficial even for OGA patients with low tumour regression; however, its efficacy appears reduced in those with lymph node metastasis, warranting further investigation into individualising treatment strategies.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70048","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T14:59:18Z","timestamp":1753196358000},"page":"2558-2568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adjuvant\n                    <scp>FLOT<\/scp>\n                    provides survival benefit for oesophagogastric junction and gastric adenocarcinoma patients with low tumour regression after neoadjuvant chemotherapy"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9275-6121","authenticated-orcid":false,"given":"Max","family":"Kraemer","sequence":"first","affiliation":[{"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Gastrointestinal Cancer Group Cologne GCGC University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naita M.","family":"Wirsik","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Cancer and Transplantation Surgery University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Alakus","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Cancer and Transplantation Surgery University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans A.","family":"Schloesser","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Cancer and Transplantation Surgery University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Cancer and Transplantation Surgery University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Cancer and Transplantation Surgery University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane J.","family":"Bruns","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Cancer and Transplantation Surgery University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Ir","family":"Lyu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital of Cologne, Institute of Pathology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Baehr","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Gastrointestinal Cancer Group Cologne GCGC University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Zander","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Gastrointestinal Cancer Group Cologne GCGC University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Quaas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital of Cologne, Institute of Pathology University of Cologne  Cologne 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