{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:19:53Z","timestamp":1783948793256,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006431","name":"Canc\u00e9rop\u00f4le Ile de France","doi-asserted-by":"publisher","award":["RINC4"],"award-info":[{"award-number":["RINC4"]}],"id":[{"id":"10.13039\/501100006431","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The management of older adults with cancer is complicated. Although the liver metabolizes most chemotherapy agents, the predictive value of the liver status in older patients with cancer remains unclear. Here, we evaluated the association of the Fibrosis\u20104 (FIB\u20104) score with overall mortality and toxicity in older patients with cancer.<\/jats:p>\n                  <jats:p>\n                    We analysed data, prior to the initiation of a new treatment modality, of patients with cancer aged over 70 enrolled into two prospective multicentre studies: ELCAPA (main cohort) and PHRC Aquitaine (external validation cohort). Treatment's toxicity was assessed after 6\u2009months and overall mortality after 6 and 12\u2009months of follow\u2010up. Of 989 patients in the main cohort (median age: 81\u2009years), 226 died during the first 6\u2009months of follow\u2010up (22%) and 355 patients (59%) experienced Grade III\/IV toxicity. A FIB\u20104 score &gt;2.67 was associated with 6\u2010 and 12\u2010month overall mortality independently of the cancer site, metastasis, chronic heart failure and serum C\u2010reactive protein level (adjusted hazard ratio [95% confidence interval, CI]\u2009=\u20091.62 [1.11\u20132.37],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.013 and 1.44 [1.07\u20131.94],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.015, respectively) and was independently associated with the occurrence of severe haematological toxicity (adjusted odds ratio [OR] [95% CI]\u2009=\u20091.92 [1.15\u20133.22],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.02). In the validation cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009333), FIB\u20104 &gt;2.67 was also independently associated with 12\u2010month overall mortality and severe haematological toxicity (adjusted OR [95% CI]\u2009=\u20091.99 [1.03\u20133.84],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.039 and 2.53 [1.52\u20134.21],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001, respectively). In conclusion, a FIB\u20104 score &gt;2.67 was independently associated with overall mortality and severe haematologic toxicity in older patients with cancer and should be considered when treating this population.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70071","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T09:55:33Z","timestamp":1754474133000},"page":"2506-2520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Fibrosis\u20104 score is associated with overall mortality and severe haematological toxicity in older patients with cancer: Analysis of two prospective cohort studies"],"prefix":"10.1002","volume":"157","author":[{"given":"Victoire","family":"de Salins","sequence":"first","affiliation":[{"name":"Department of Geriatrics Universit\u00e9 Paris Cit\u00e9, European Georges Pompidou Hospital, Paris Cancer Institute CARPEM, Assistance\u2010Publique H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Martinez\u2010Tapia","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, INSERM, IMRB  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Gay","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Universit\u00e9 Paris Cit\u00e9, European Georges Pompidou Hospital, Paris Cancer Institute CARPEM, Assistance\u2010Publique H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Morel","sequence":"additional","affiliation":[{"name":"Department of Nephrology P\u2010HP, Henri Mondor Hospital  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bringuier","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Institut Curie  Saint\u2010Cloud France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-305X","authenticated-orcid":false,"given":"Pascaline","family":"Boudou\u2010Rouquette","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cochin Hospital, Paris Cancer Institute CARPEM Universit\u00e9 Paris Cit\u00e9, Assistance\u2010Publique H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lola","family":"Corsin","sequence":"additional","affiliation":[{"name":"Department of Geriatrics APHP, Albert Chenevier Hospital  Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Aregui","sequence":"additional","affiliation":[{"name":"Oncogeriatrics Coordination Unit, Paris Nord Hospitals Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Canovas","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Universit\u00e9 Paris Cit\u00e9, European Georges Pompidou Hospital, Paris Cancer Institute CARPEM, Assistance\u2010Publique H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Emmanuel","family":"Rautou","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Cit\u00e9, INSERM, Centre de Recherche sur l'Inflammation, UMR 1149  Paris France"},{"name":"Service d'H\u00e9patologie, AP\u2010HP, H\u00f4pital Beaujon, DMU DIGEST, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE\u2010LIVER  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Soubeyran","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Institut Bergoni\u00e9 Regional Comprehensive Cancer Centre  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Bellera","sequence":"additional","affiliation":[{"name":"Bordeaux Population Health Research Center Bordeaux University, Epicene Team, UMR 1219  Bordeaux France"},{"name":"Inserm CIC1401, Clinical and Epidemiological Research Unit Institut Bergoni\u00e9, Comprehensive Cancer Center  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Canoui\u2010Poitrine","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, INSERM, IMRB  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Paillaud","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Universit\u00e9 Paris Cit\u00e9, European Georges Pompidou Hospital, Paris Cancer Institute CARPEM, Assistance\u2010Publique H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"Univ Paris Est Cr\u00e9teil, INSERM, IMRB  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-845X","authenticated-orcid":false,"given":"Johanne","family":"Poisson","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Universit\u00e9 Paris Cit\u00e9, European Georges Pompidou Hospital, Paris Cancer Institute CARPEM, Assistance\u2010Publique H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"Universit\u00e9 Paris\u2010Cit\u00e9, INSERM, Centre de Recherche sur l'Inflammation, UMR 1149  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20073"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.8983"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.9894"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02063"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv025"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi039"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8347"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.120"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S57849"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/bega.2002.0271"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2005.06.009"},{"issue":"8","key":"e_1_2_12_13_1","first-page":"1057","article-title":"Chemotherapy dosing in the setting of liver dysfunction","volume":"19","author":"Eklund JW","year":"2005","journal-title":"Oncology (Williston Park)"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15073"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000176"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2006.00556.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478\u20103231.2011.02629.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.7625"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010019\u201003821\u20106"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.025"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29302"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2019.01.017"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201000509\u2010x"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.719802"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013696"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.655343"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010020\u201008828\u20105"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr587"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(98)00171-3"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1963.03060120024016"},{"issue":"4","key":"e_1_2_12_31_1","first-page":"609","article-title":"Scales to measure competence in everyday activities","volume":"24","author":"Lawton MP","year":"1988","journal-title":"Psychopharmacol Bull"},{"issue":"2","key":"e_1_2_12_32_1","first-page":"91","article-title":"Development and contribution to the validation of a brief French version of the Yesavage Geriatric Depression Scale","volume":"23","author":"Cl\u00e9ment JP","year":"1997","journal-title":"Encephale"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.1968.tb02103.x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.453"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010320995"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895\u20104356(95)00048\u20108"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895\u20104356(96)00236\u20103"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.11509"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603\u2010016\u20100734\u2010x"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0277729"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.04.026"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2020.10.014"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11175149"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.15_suppl.12050"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14669"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:55:57Z","timestamp":1761123357000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,6]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,15]]}},"alternative-id":["10.1002\/ijc.70071"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70071","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,6]]},"assertion":[{"value":"2024-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}