{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:05:13Z","timestamp":1789589113229,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012538","name":"Swedish Cancer Foundation","doi-asserted-by":"publisher","award":["23 2700 Pj"],"award-info":[{"award-number":["23 2700 Pj"]}],"id":[{"id":"10.13039\/100012538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003514","name":"Kommunfullm\u00e4ktige, Stockholms Stad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003514","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The incidence of human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC) has increased the past decades. Initial reports disclosed that HPV type 16 (HPV16) was predominant and that patients with HPV+ OPSCC were generally younger and had a better prognosis than those with HPV negative (HPV\u2212) OPSCC. However, recent reports suggest that age differences between patients with HPV+ and HPV\u2212OPSCC are less pronounced and that other high\u2010risk HPV types (HR\u2010HPV) are becoming more common. Here, we therefore investigated whether there were age differences between patients with HPV16\u2010positive and other HR\u2010HPV type positive OPSCC. During 2000\u20132022, in the Stockholm\u2013Gotland\u2010Region, Sweden, 1681 patients with OPSCC tested for the presence of common mucosal HPV types were included. Among these, 1180 cases had a HR\u2010HPV type infection, with 1032 identified as HPV16 and 148 as other HR\u2010HPV types; one with a low\u2010risk HPV type infection; and 500 classified as HPV\u2212. Patients with HPV+ OPSCC were significantly younger than those with HPV\u2212 OPSCC (mean 63 vs. 66.5,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;.001). Among patients with HPV+ OPSCC, those diagnosed with HPV16 were significantly younger than those with other HR\u2010HPV types (mean 61.1 vs. 64.5,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.001). These age differences were present irrespective of sex, but patients with HPV16\u2010positive OPSCC were significantly more likely to present with smaller tumours upon diagnosis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). Moreover, notably, statistically significant age differences between HPV16 and other HR\u2010HPV types were mainly observed in the more recent years (2010\u20132022). To conclude, the increasing influence of HR\u2010HPV types other than HPV16 in OPSCC warrants further investigation.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70087","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T15:59:22Z","timestamp":1755273562000},"page":"2019-2024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Age and tumour presentations differ between\n                    <scp>HPV<\/scp>\n                    type 16 positive and other high\u2010risk\n                    <scp>HPV<\/scp>\n                    type\u2010positive oropharyngeal squamous cell carcinomas in a Swedish cohort of 2000\u20132022"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4602-4297","authenticated-orcid":false,"given":"Anders","family":"N\u00e4sman","sequence":"first","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Pathology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Birgersson","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"N\u00e4sman","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Pathology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2031-9866","authenticated-orcid":false,"given":"Evelina","family":"J\u00f6rts\u00f6","sequence":"additional","affiliation":[{"name":"Medical Unit Head, Neck, Lung, and Skin Cancer, Theme Cancer Karolinska University Hospital  Stockholm Sweden"},{"name":"Division of Ear Nose and Throat Diseases, Department of Clinical Sciences Intervention and Technology Karolinska Institutet  Stockholm Sweden"},{"name":"Medical Unit Otorhinolaryngology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4013-7688","authenticated-orcid":false,"given":"Mark","family":"Zupancic","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"},{"name":"Medical Unit Head, Neck, Lung, and Skin Cancer, Theme Cancer Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9325-2992","authenticated-orcid":false,"given":"Rusana","family":"Bark","sequence":"additional","affiliation":[{"name":"Medical Unit Head, Neck, Lung, and Skin Cancer, Theme Cancer Karolinska University Hospital  Stockholm Sweden"},{"name":"Division of Ear Nose and Throat Diseases, Department of Clinical Sciences Intervention and Technology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Marklund","sequence":"additional","affiliation":[{"name":"Medical Unit Head, Neck, Lung, and Skin Cancer, Theme Cancer Karolinska University Hospital  Stockholm Sweden"},{"name":"Division of Ear Nose and Throat Diseases, Department of Clinical Sciences Intervention and Technology Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Surgical Sciences, Section of Otolaryngology and Head and Neck Surgery Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7022-2424","authenticated-orcid":false,"given":"Tina","family":"Dalianis","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"},{"name":"Medical Unit Head, Neck, Lung, and Skin Cancer, Theme Cancer Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31385"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.0310"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25585"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00370"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13010"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010022\u201000603\u20107"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.35099"},{"key":"e_1_2_12_9_1","volume-title":"IARC Monographs on the Evaluation of Carcinogenic Risk to 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