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This observational study aims to investigate cancer incidence trends among young adults under 50, compared to older age trends, using the population\u2010based Cancer Registry of the Veneto Region (Northeastern Italy) from 1987 to 2019. Yearly age\u2010standardized cancer incidence rates per 100,000 individuals were obtained from the Veneto Tumour Registry for 24 tumor sites and all cancers combined. Temporal trends from 1987 to 2019 were analyzed for each cancer type, stratified by sex and age group at diagnosis (0\u201349, 50\u201364, and 65+ years). Significant changes in incidence trends were assessed by the annual percent change (APC), calculated through joinpoint regression analysis. Since 1987, the incidence rate of cancers among young adults decreased in males, while among females it increased until 2014 and then stabilized. One cancer showed increasing incidence in both sexes (invasive cutaneous melanoma), two in males (testicular, and multiple myeloma), and two more in females (breast, and Hodgkin disease). Four cancer sites showed a decline in both sexes (oral cavity, stomach, lung, and bladder), and four further cancers only in males (esophagus, rectum, larynx, and non\u2010Hodgkin lymphoma). Two cancers showed complex trends (Corpus uteri, and thyroid in women). Eight cancers showed no significant changes in APCs. Cancer incidence data for young adults reveal a heterogeneous landscape. These findings provide valuable insights into the expected evolution of cancer epidemiology in young populations.<\/jats:p>","DOI":"10.1002\/ijc.70088","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T15:05:24Z","timestamp":1755356724000},"page":"532-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Is the incidence of early\u2010onset cancers increasing in the northeast of Italy? A 30\u2010year analysis of the regional cancer registration data by age, 1987\u20132019"],"prefix":"10.1002","volume":"158","author":[{"given":"Alessandra","family":"Buja","sequence":"first","affiliation":[{"name":"Department of Cardiological, Thoracic, Vascular Sciences and Public Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6063-7930","authenticated-orcid":false,"given":"Chiara","family":"Trevisiol","sequence":"additional","affiliation":[{"name":"Soft\u2010Tissue, Peritoneum, and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Miatton","sequence":"additional","affiliation":[{"name":"Department of Cardiological, Thoracic, Vascular Sciences and Public Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Guzzinati","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry, Azienda Zero  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Bovo","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry, Azienda Zero  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Mocellin","sequence":"additional","affiliation":[{"name":"Soft\u2010Tissue, Peritoneum, and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"},{"name":"Department of Surgery, Oncology, and Gastroenterology \u2013 DISCOG University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Fantin","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Rugge","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Pathology and Cytopathology Unit University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Bronte","sequence":"additional","affiliation":[{"name":"Scientific Directorate, Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6025-5214","authenticated-orcid":false,"given":"Manuel","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry, Azienda Zero  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_13_3_1","unstructured":"National Cancer Institute.Cancer among adolescents and young adults (AYAs) \u2013 cancer stat facts [Internet]. 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