{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:11:41Z","timestamp":1792606301575,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010711","name":"Sy\u00f6p\u00e4s\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["230070"],"award-info":[{"award-number":["230070"]}],"id":[{"id":"10.13039\/501100010711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human papillomavirus (HPV) genotypes possess different cervical high\u2010grade intraepithelial lesion and cancer (CIN2+) risks. HPV genotyping is a promising method to increase the specificity of primary HPV screening, but the optimal management of the infections with different genotypes has not been established. We aimed to assess long\u2010term HPV genotype\u2010specific CIN2+ risks, stratified by age and triage cytology result in a population\u2010based cervical cancer screening program. This is a prospective study of 5253 HPV\u2010positive individuals from the Finnish randomized HPV screening trial, with up to 18\u2009years of follow\u2010up. HPV\u2010positive samples were genotyped using Luminex and BD Onclarity assays. The genotyping data were linked to data from four different nationwide health registries. The primary outcome was HPV genotype\u2010specific cumulative incidence of CIN2+. The CIN2+ cumulative incidence was the highest for HPV16 (38.1%), followed by HPV33\/58 (25.4%) and HPV31 (22.2%). The lowest incidences were observed for HPV56\/59\/66 (4.4%), HPV35\/39\/68 (6.5%), and HPV51 (7.5%). Individuals aged 50 or older at the entry test had lower cumulative incidences for the highest\u2010risk genotypes. The cytology stratification showed that for the infections with the highest risks, normal cytology triage did not guarantee a low CIN2+ risk. On the other hand, HPV51 and HPV56\/59\/66 had a low risk even with an abnormal cytology result. The findings suggest that individuals with HPV16, HPV33\/58, and HPV31 infections could be referred immediately to colposcopy. Sending individuals with low\u2010risk genotypes, HPV35\/39\/68, HPV51, or HPV56\/59\/66 infections with normal cytology back to routine screening could increase screening specificity.<\/jats:p>","DOI":"10.1002\/ijc.70123","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T10:10:35Z","timestamp":1756721435000},"page":"931-941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term human papillomavirus genotype\u2010specific risk of cervical high\u2010grade intraepithelial lesion and cancer\u2014By age group and triage cytology"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4849-1211","authenticated-orcid":false,"given":"Maija","family":"Vahteristo","sequence":"first","affiliation":[{"name":"Finnish Cancer Registry  Helsinki Finland"},{"name":"Department of Public Health Faculty of Medicine, University of Helsinki  Helsinki 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