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Platinum\u2010based agents, such as cisplatin and carboplatin, along with taxanes, including paclitaxel and docetaxel, represent fundamental therapies for OC. However, the immunomodulatory effects of these agents on the tumor microenvironment are multifaceted and can be perceived as a double\u2010edged sword. Chemotherapeutics not only trigger cytotoxic effects but also influence the networks of pro\u2010 and anti\u2010tumor cytokines, playing a role in both treatment efficacy and resistance. We specifically examine cytokine\u2010mediated mechanisms underlying both platinum\u2010based and taxane\u2010based chemoresistance in OC. In this review, we comprehensively examine how platinum and taxane chemotherapy modulate cytokine signaling in OC, focusing on key mediators like interleukin (IL) 6, IL\u20108, transforming growth factor\u2010beta, and C\u2010X\u2010C motif ligand 2 that drive survival pathways and chemoresistance. Interestingly, these agents might enhance anti\u2010tumor immunity via interferon\u2010gamma and IL\u201012, revealing the potential for synergistic chemoimmunotherapy. This research provides valuable insights for addressing resistance and improving combination therapies through the analysis of the dual roles of chemotherapy in modulating cytokine dynamics in OC.<\/jats:p>","DOI":"10.1002\/ijc.70132","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T08:51:37Z","timestamp":1757926297000},"page":"1141-1155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chemotherapy as a double\u2010edged sword: Modulation of tumor\u2010associated cytokine and chemokine responses in ovarian cancer"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-0064","authenticated-orcid":false,"given":"Amin","family":"Ullah","sequence":"first","affiliation":[{"name":"Department of Targeting Therapy and Immunology, Cancer Center, Institutes for Systems Genetics, Frontiers Science Center for Disease\u2010related Molecular Network, West 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