{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:07:38Z","timestamp":1776107258571,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014688","name":"Region Uppsala","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007051","name":"Uppsala Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2022\u201000544"],"award-info":[{"award-number":["2022\u201000544"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["19 00 30"],"award-info":[{"award-number":["19 00 30"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A family history of prostate cancer in first\u2010degree relatives is an established risk factor for prostate cancer, but the specific associations between prostate cancer characteristics in fathers and the risk of high\u2010risk prostate cancer in their sons remain unclear. We identified men in Prostate Cancer data Base Sweden whose fathers had been diagnosed with prostate cancer in 1998\u20132005. We compared the observed number of prostate cancer diagnoses in these men with the expected number in the Swedish male population, estimating standardized incidence ratios (SIR). The median age of the 25,287 included sons of men with prostate cancer was 52\u2009years (interquartile range 47\u201357\u2009years) at end of follow\u2010up. Their overall risk of a prostate cancer diagnosis was higher if the father had been diagnosed at less than 65\u2009years old (SIR, 4.3, 95% confidence interval [CI], 3.8\u20135.0), compared with having a father diagnosed when 70\u2009years old or older (SIR, 2.3; 95% CI 1.9\u20132.8). Sons of fathers diagnosed at less than 65 had a higher risk of Gleason score \u22658 cancers (SIR, 2.3; 95% CI 1.1\u20134.1) than sons of fathers diagnosed at 70\u2009years old or older (SIR, 1.2; 95% CI 0.4\u20132.6). Having a father with a Gleason \u22658 cancer was associated with an increased risk for a Gleason \u22658 cancer (SIR, 2.6; 95% CI 1.1\u20135.1). These population\u2010based results suggest that the father's prostate cancer characteristics should be considered when counseling men on prostate\u2010specific antigen testing and diagnostic strategies.<\/jats:p>","DOI":"10.1002\/ijc.70133","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T06:10:21Z","timestamp":1757484621000},"page":"977-983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prostate cancer characteristics in fathers and risk of early onset high\u2010risk prostate cancer in sons"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-1866","authenticated-orcid":false,"given":"E","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Garmo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9798-1479","authenticated-orcid":false,"given":"Kerri","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology and Population Health Research Group, Allied Health and Human Performance University of South Australia  Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Bratt","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Urology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olof","family":"Akre","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institute  Stockholm Sweden"},{"name":"Department of Pelvic Cancer Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4r","family":"Stattin","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-7863","authenticated-orcid":false,"given":"Rolf","family":"Gedeborg","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027130"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.09.042"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003491"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70282-6"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.5664"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.02.032"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2022.2107069"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2022.2094462"},{"key":"e_1_2_13_10_1","first-page":"1","article-title":"The Swedish national guidelines on prostate cancer, part 2: recurrent, metastatic and castration resistant disease","volume":"56","author":"Bratt O","year":"2022","journal-title":"Scand J Urol"},{"key":"e_1_2_13_11_1","volume-title":"Data Quality in the National Prostate Cancer Register (NPCR) of Sweden","author":"Tomi\u0107 K","year":"2018"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys068"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-423-0_10"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0050"},{"key":"e_1_2_13_15_1","volume-title":"Statistical Methods in Cancer Research Volume II\u2013The Design and Analysis of Cohort Studies","author":"Breslow 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