{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:34:14Z","timestamp":1784673254076,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Given the poor survival and relatively poor performance of hepato\u2010pancreato\u2010biliary (HPB) cancers on data quality indicators for cancer registries, we assessed trends in incidence, survival, and data quality of HPB cancers within the Netherlands Cancer Registry (NCR). All primary solid liver, gallbladder, biliary tract, and pancreatic cancers (topography C22\u201023\u201024\u201025) diagnosed between 1989 and 2022 were included (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009109,552). Cancer mortality data were obtained from Statistics Netherlands. For incidence and mortality, revised European Age\u2010Standardised Rates, and for survival, age\u2010standardised 5\u2010year relative survival (AS\u20105yRS) were calculated. Over time, incidence rates increased for liver (males: 3.0 to 8.2\/100,000; females 1.2 to 3.9\/100,000), pancreatic (males: 15.8 to 18.5\/100,000; females: 11.1 to 15.3\/100,000), and biliary tract cancers in males (3.9 to 4.9\/100,000; not females: 3.3 to 2.9\/100,000). Gallbladder cancer incidence decreased until 2005 (males: 1.5 to 0.8\/100,000, females 4.0 to 1.5\/100,000). Mortality trends mirrored incidence patterns, with smaller increases. AS\u20105yRS improved across all HPB cancers with the largest increase in liver (males: 3.4% to 20.8%; females: 6.7% to 18.3%) and pancreatic cancers (males: 2.3% to 10.4%; females: 3.5% to 11.3%). Since 2010, survival gains for gallbladder (males: 8.4% to 16.3%; females: 12.2% to 15.8%) and biliary tract cancers (males: 11.7% to 19.1%; females: 10.7% to 15.6%) have stagnated. Mortality\u2010to\u2010Incidence ratios versus 5\u2010year relative survival for liver and pancreatic cancers improved toward equilibrium. Data quality improved (e.g., autopsy, unspecified morphology) or remained stable (multiple primaries). Both incidence and survival rates of primary HPB cancers have increased over time. Increased completeness of incidence data was attributed to changed notification sources.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70145","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T14:52:25Z","timestamp":1757688745000},"page":"1237-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increased incidence, survival, and registration quality of primary hepato\u2010pancreato\u2010biliary cancers in the Netherlands Cancer Registry"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-5520","authenticated-orcid":false,"given":"Lydia G.","family":"van der Geest","sequence":"first","affiliation":[{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht The Netherlands"},{"name":"Department of Medical Oncology Amsterdam UMC, Location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"van der Mark","sequence":"additional","affiliation":[{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Verheij","sequence":"additional","affiliation":[{"name":"Department of Pathology Amsterdam UMC, Location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantza","family":"Farina Sarasqueta","sequence":"additional","affiliation":[{"name":"Department of Pathology Amsterdam UMC, Location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2578-1766","authenticated-orcid":false,"given":"Judith","family":"de Vos\u2010Geelen","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"GROW\u2014Research Institute for Oncology &amp; Reproduction Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc G.","family":"Besselink","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC, Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Treatment and Quality of Life Cancer Center Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent E.","family":"de Meijer","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Groningen and University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignace H. J. T.","family":"de Hingh","sequence":"additional","affiliation":[{"name":"GROW\u2014Research Institute for Oncology &amp; Reproduction Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Surgery Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert A.","family":"Bonsing","sequence":"additional","affiliation":[{"name":"Department of Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"de Reuver","sequence":"additional","affiliation":[{"name":"Department of Surgery Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois E. J. 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