{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T05:26:31Z","timestamp":1766035591659,"version":"3.48.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473242"],"award-info":[{"award-number":["82473242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to determine dosimetric and clinical predictors of radiation esophagitis (RE) in breast cancer patients undergoing conventional fractionated regional nodal irradiation (RNI). Eligible patients received radiotherapy (RT; 50\u2009Gy in 25 fractions) to the chest wall, supraclavicular\/infraclavicular fossa, level II axilla, and\/or internal mammary chain. RE was graded weekly during RT and at weeks 1, 2 and months 3, 6 post\u2010RT (CTCAE v3.0). The esophagus was contoured from the lower edge of cricoid cartilage to aortic arch. Esophageal parameters included mean dose (Dmean), maximum dose (Dmax), relative (RV5\u2013RV45) and absolute volumes (AV5\u2013AV45) receiving 5\u201345 Gy in 5\u2010Gy increments. Univariate and multivariate analyses identified predictors of grade \u22652 RE. Among 541 prospectively enrolled patients (minimum 6\u2009months follow\u2010up), 271 (50.1%) had left\u2010sided breast cancer. Grade 2 RE was 23.7% (128\/541), with no grade \u22653 RE. Tumor laterality (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001) was the only clinical risk factor. Esophageal Dmean, Dmax, RV20\u2013RV40, and AV20\u2013AV35 were dosimetric parameters of grade \u22652 RE in univariate analysis. Multivariate analysis identified RV30 &lt;9% (13.9% vs. 31.3%) and AV30 &lt;1\u2009mL (15.2% vs. 30.5%) as optimal dosimetric predictors. Therefore, RE is common in patients receiving RNI, with tumor laterality being the clinical risk factor. Limiting upper esophagus RV30 &lt;9% and AV30 &lt;1\u2009mL may reduce RE risk.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70161","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T15:55:54Z","timestamp":1758210954000},"page":"1055-1066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dosimetric and clinical predictors for radiation esophagitis in patients with breast cancer undergoing conventional fractionated regional nodal irradiation: A prospective study"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7067-0436","authenticated-orcid":false,"given":"Dan\u2010Qiong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Xing","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy The Fourth Hospital of Hebei Medical University\/Hebei Cancer Hospital  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital &amp; Institute  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Fei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Affiliated Taizhou Hospital of Wenzhou Medical University  Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Tie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology Peking University Cancer Hospital and Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Rong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Peking Union Medical College Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiochemotherapy Tangshan People's Hospital  Tangshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-5837","authenticated-orcid":false,"given":"Ya\u2010Hua","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Li","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8569-8214","authenticated-orcid":false,"given":"Qiu\u2010Zi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Beijing Hospital, Ministry of Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy The Fourth Hospital of Hebei Medical University\/Hebei Cancer Hospital  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital &amp; Institute  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Rui","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0985-235X","authenticated-orcid":false,"given":"Ye\u2010Xiong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Na","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Xijing Hospital, The Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Lian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60488-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.03.014"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds144"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.10.042"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08852-y"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.04.012"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.03.060"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn029"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-9-161"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.01.005"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-3166-5"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007956"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2017.04.007"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39469-8"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12943"},{"key":"e_1_2_12_17_1","first-page":"2265","article-title":"Assessment of acute toxicities and early local recurrences in post mastectomy breast cancer patients by accelerated hypofractionated radiotherapy; a single arm clinical trial","volume":"25","author":"Vijayaraghavan N","year":"2020","journal-title":"J BUON"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83159-3"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2021.08.004"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/jmp.jmp_84_22"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/crst.crst_10_23"},{"key":"e_1_2_12_22_1","unstructured":"Radiation Therapy Oncology Group.Breast cancer atlas for radiation therapy planning: consensus definitions. 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