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While they can enhance anti\u2010tumor immunity through antibody production and immune activation, certain subsets\u2014such as regulatory B cells (Bregs) and immunosuppressive plasma cells\u2014contribute to immune evasion by secreting inhibitory factors. In this review, we analyze TIB heterogeneity, with a particular focus on their differentiation pathways, including the distinct roles of germinal center (GC) and extrafollicular (EF) responses in immune regulation. We further summarize the diverse functions of TIBs in tumor immunity, exploring their metabolic adaptations and defects in antibody maturation. 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