{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:04:40Z","timestamp":1767589480136,"version":"3.48.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This multicenter, randomized phase III clinical trial assesses the efficacy and toxicity of SIB\u2010RT with\/without concurrent chemotherapy in patients with inoperable esophageal squamous cell carcinoma (ESCC) in the era of intensity\u2010modulated RT and was conducted between December 2017 and November 2020. Patients with inoperable clinical stage II\u2013III diseases or clinical stage IV disease with metastatic lymph nodes in supraclavicular\/celiac trunk area were enrolled and randomized to receive SIB\u2010RT concurrent with chemotherapy (SIB\u2010RT\u2009+\u2009CT arm,\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200982) or SIB\u2010RT alone (SIB\u2010RT arm,\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200982). Planning gross tumor volume and planning target volume were administered with 59.92 and 50.4\u2009Gy of radiation, respectively, in 28 fractions. The concurrent chemotherapy regimen comprised weekly doses of paclitaxel and nedaplatin for 5\u2009weeks. The primary endpoint was overall survival (OS). The secondary endpoints were treatment response, progression\u2010free survival (PFS), quality of life (QoL), and toxicity profiles. The SIB\u2010RT\u2009+\u2009CT arm exhibited a superior treatment response to that in SIB\u2010RT arm (69.5% vs. 53.7%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.04). The 5\u2010year OS in SIB\u2010RT arm and SIB\u2010RT\u2009+\u2009CT arm was 23.9% vs. 28.8% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.33). The 5\u2010year PFS in SIB\u2010RT arm and SIB\u2010RT\u2009+\u2009CT arm was 23.9% vs. 27.4% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.22). The improvement of EORTC QLQ\u2010OES18 dysphagia subscale score was higher in SIB\u2010RT\u2009+\u2009CT arm compared with SIB\u2010RT arm (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.02). The incidences of grade 3 or higher leukopenia and nausea were higher in SIB\u2010RT\u2009+\u2009CT arm (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.01 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.01). SIB\u2010RT should be realized as the essential treatment modality for inoperable ESCC. SIB\u2010RT\u2009+\u2009CT should be the preferred treatment option, as it affords a superior treatment response and greater dysphagia relief.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70176","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T07:01:43Z","timestamp":1760511703000},"page":"1312-1322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Simultaneous integrated boost intensity\u2010modulated radiotherapy with or without concurrent chemotherapy in patients with esophageal squamous cell carcinoma: A multicenter, open\u2010label, randomized, phase\n                    <scp>III<\/scp>\n                    clinical trial"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1770-6117","authenticated-orcid":false,"given":"Weiming","family":"Han","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology National Cancer 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