{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:04:37Z","timestamp":1767589477768,"version":"3.48.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/01225"],"award-info":[{"award-number":["PI20\/01225"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The detection of advanced adenomas (AA) is an important benefit\u2010relevant indicator in colorectal cancer screening programmes (CRCSP). The study hypothesis is that factors related to personal screening history and social characteristics may influence the risk of detecting AA. We performed a retrospective study of men and women aged between 50 and 69 who participated in the Valencia Region CRCSP between 2010 and 2018. Variables: sex, age, number of previous negative faecal occult blood tests (FOBT), and faecal Hb concentration in the previous FOBT (Prev\u2010f\u2010Hb). We analysed the risk of AA and the influence of factors related to screening history in the first screening attendance (First_A) (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009594,242) and in the most recent screening attendance (Recent_A) (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009388,558) for people who had participated on at least two occasions. Logistic multivariate models were used to estimate odds ratios (OR). The risk of AA in First_A was higher in men (OR\u2009=\u20092.59; 2.50\u20132.68) and in the 60\u201369 age group (OR\u2009=\u20091.62; 1.57\u20131.67). In Recent_A, the risk was higher in the population with a Prev\u2010f\u2010Hb of greater than 0\u2009ng\/mL, and this risk increased for 0.1\u201319.9\u2009ng\/mL, 20\u201339.9\u2009ng\/mL, 40\u201359.9\u2009ng\/mL, 60\u201379.9\u2009ng\/mL, and 80\u201399.9\u2009ng\/mL (women: OR\u2009=\u20091.70, OR\u2009=\u20093.78, OR\u2009=\u20097.05, OR\u2009=\u20099.98, OR\u2009=\u200914.1 and men: OR\u2009=\u20091.66, OR\u2009=\u20093.61, OR\u2009=\u20095.69, OR\u2009=\u20098.45, OR\u2009=\u200910.30, respectively). The risk was lower in the population with four or five previous negative FOBT (OR\u2009=\u20090.76, 0.68\u20130.85; OR\u2009=\u20090.53, 0.41\u20130.66). Demographic characteristics and screening history could be used to design risk\u2010adapted screening strategies.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70182","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:38:09Z","timestamp":1759793889000},"page":"1272-1280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of advanced adenoma detection in colorectal cancer screening programmes according to personal characteristics and screening history"],"prefix":"10.1002","volume":"158","author":[{"given":"Mercedes","family":"Vanaclocha\u2010Esp\u00ed","sequence":"first","affiliation":[{"name":"Foundation for the Promotion of Health and Biomedical Research\u2010Public Health Research FISABIO\u2013Public Health Research  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Romeo\u2010Cervera","sequence":"additional","affiliation":[{"name":"Foundation for the Promotion of Health and Biomedical Research\u2010Public Health Research FISABIO\u2013Public Health Research  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Castan\u2010Cameo","sequence":"additional","affiliation":[{"name":"General Directorate of Public Health  Valencia Region Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"P\u00e9rez\u2010Sanz","sequence":"additional","affiliation":[{"name":"General Directorate of Public Health  Valencia Region Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefa","family":"Iba\u00f1ez","sequence":"additional","affiliation":[{"name":"General Directorate of Public Health  Valencia Region Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crist\u00f3bal","family":"Llorens\u2010Ivorra","sequence":"additional","affiliation":[{"name":"General Directorate of Public Health  Valencia Region Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Risue\u00f1o\u2010Albuixech","sequence":"additional","affiliation":[{"name":"General Directorate of Public Health  Valencia Region Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Bes\u00f3","sequence":"additional","affiliation":[{"name":"Manises Hospital, Preventive Medicine Service  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Molina\u2010Barcel\u00f3","sequence":"additional","affiliation":[{"name":"Foundation for the Promotion of Health and Biomedical Research\u2010Public Health Research FISABIO\u2013Public Health Research  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Global Cancer Observatory.Global Cancer Observatory. 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