{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:25:45Z","timestamp":1792531545103,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012095","name":"Scottish Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vaccination against high\u2010risk HPV has been shown to reduce significantly the incidence of pre\u2010invasive and invasive cervical disease. Clinical trials show immunity and vaccine effectiveness for over 12\u2009years but real\u2010life longitudinal data are lacking. Vaccination with the bivalent vaccine (3 dose schedule) for women aged 12\u201318\u2009years began in Scotland in 2008; immunised women entered screening in 2010. Women immunised at age12\u201313\u2009years entered screening in 2015. Linked data from \u226412\u2009years of routine screening activity shows adjusted VE against CIN2+ at age 12\u201313 of 72\u00b76% (95%CI: 67.7\u201376.8) and at age 14\u201316 of 63\u00b72 (CI 60\u00b74\u201365\u00b78), and against CIN3+ of 81\u00b77 (CI 76\u00b72\u201378\u00b76; age 12\u201313) and 68\u00b71 (CI 64\u00b71\u201371\u00b76; age 14\u201316) after 3 doses or two doses 5\u2009months apart. Adjusted VE following two doses 1\u2009month apart or one dose only at age14 was 20.5 (95%CI: 6.1\u201332.6) for CIN2+ and 34.9 (95%CI:17.0\u201348.9) for CIN3+. No benefit was seen with vaccination over the age of 18\u2009years. The most deprived women showed the highest incidence of CIN2+ and CIN3+, and the greatest reduction in CIN2+ and CIN3+ following complete immunisation. Herd protection is seen in all immunised cohorts. This population based analysis confirms the long\u2010term effectiveness of the bivalent HPV vaccine, greatest in women from the most deprived areas and reinforces the importance of ensuring high vaccine uptake rates at an early age.<\/jats:p>","DOI":"10.1002\/ijc.70183","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T06:32:24Z","timestamp":1762237944000},"page":"1348-1360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sustained impact of bivalent\n                    <scp>HPV<\/scp>\n                    immunisation on\n                    <scp>CIN<\/scp>\n                    incidence over two rounds of cervical screening"],"prefix":"10.1002","volume":"158","author":[{"given":"Timothy J.","family":"Palmer","sequence":"first","affiliation":[{"name":"Public Health Scotland  Glasgow UK"},{"name":"MRC Centre for Reproductive Health University of Edinburgh  Edinburgh 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