{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:37:31Z","timestamp":1789778251708,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["09150161810003"],"award-info":[{"award-number":["09150161810003"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cancer is increasingly prevalent among older adults with geriatric impairments, yet the impact of frailty on immune checkpoint inhibitor (ICI) therapy outcomes remains underexplored. This study aims to assess the association between frailty and grade \u22653 immune\u2010related adverse events (irAEs), clinical benefit, all\u2010cause hospitalization, and mortality in older patients undergoing ICI therapy. Patients aged \u226565\u2009years, treated with anti\u2010PD\u20101 monotherapy for a solid malignancy (September 2018\u2013February 2024), were prospectively included in this multicenter study. The association between frailty, components of the geriatric assessment, and number of impaired geriatric domains with the occurrence of grade \u22653 irAEs, all\u2010cause hospitalization, and clinical benefit was analyzed using univariable and multivariable logistic regression. Cox proportional hazards models were used to analyze all\u2010cause mortality. Among the 110 patients, 55% were classified as frail. Grade \u22653 irAEs occurred in 17.3%, with no significant difference between frail and non\u2010frail patients (18.0% vs. 16.4%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.814). Frailty was associated with higher hospitalization (OR: 3.98, 95%C.I.: 1.20\u201313.19) and mortality risk (HR: 5.23, 95%C.I.: 1.81\u201315.11). Multimorbidity (Charlson comorbidity index score \u22653) was also associated with hospitalization (OR: 5.54, 95%C.I.: 1.81\u201316.99). Frailty and the number of impaired geriatric domains were not associated with clinical benefit of ICIs in the palliative treatment setting (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.374, and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.155, respectively). Frailty should not be considered a contraindication for ICI therapy, as this therapy is generally well\u2010tolerated, even among older frail patients. Instead, frailty should be viewed as a relevant clinical factor for optimizing therapeutic decision\u2010making and tailoring supportive interventions in older patients.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70185","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:24:27Z","timestamp":1759591467000},"page":"1370-1382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of geriatric impairments on outcomes of single\u2010agent immunotherapy in solid tumors"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6729-9479","authenticated-orcid":false,"given":"Asli","family":"\u00d6zkan","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlijn","family":"de Joode","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Kapiteijn","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marije","family":"Slingerland","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Zunder","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederiek","family":"van den Bos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gerontology and Geriatrics Leiden University Medical Center  Leiden The Netherlands"},{"name":"LUMC Center for Medicine for Older People Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Mooijaart","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gerontology and Geriatrics Leiden University Medical Center  Leiden The Netherlands"},{"name":"LUMC Center for Medicine for Older People Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Uit den Boogaard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gerontology and Geriatrics Leiden University Medical Center  Leiden The Netherlands"},{"name":"LUMC Center for Medicine for Older People Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Trompet","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gerontology and Geriatrics Leiden University Medical Center  Leiden The Netherlands"},{"name":"LUMC Center for Medicine for Older People Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Westgeest","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Amphia Hospital  Breda The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"van der Veldt","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Erasmus University Medical Center  Rotterdam The Netherlands"},{"name":"Department of Radiology &amp; Nuclear Medicine Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron H. 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