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The role of anti\u2010HBV prophylaxis in preventing HBV reactivation in T\u2010cell lymphoma (TCL) patients with resolved HBV infection remains unclear. We retrospectively included TCL patients with resolved HBV infection (hepatitis B surface antigen negative and HBV core antibody positive) who received anti\u2010lymphoma treatment at Sun Yat\u2010sen University Cancer Center between March 2004 and February 2024. Patients were categorized into the prophylaxis and non\u2010prophylaxis groups based on whether they received prophylactic anti\u2010HBV treatment. Propensity score matching (PSM) with a 1:1 ratio was conducted to balance the differences in baseline characteristics between the two groups. The primary endpoint was the HBV reactivation rate. A total of 174 eligible patients were included in the PSM cohort. After matching, no significant differences were observed in baseline characteristics between the prophylaxis group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200987) and non\u2010prophylaxis group (n\u2009=\u200987). With a median follow\u2010up of 24.0\u2009months (IQR, 11.0\u201338.5), the HBV reactivation rate was 0% (0\/87) and 5.7% (5\/87) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.059) in the prophylaxis group and non\u2010prophylaxis group, respectively. Patients in the non\u2010prophylaxis group showed a higher cumulative HBV reactivation rate than those in the prophylaxis group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.025). All the five patients who experienced HBV reactivation had encountered delays or discontinuation in their anti\u2010lymphoma therapy. These findings show that TCL patients with resolved HBV infection who received anti\u2010HBV prophylaxis had a lower rate of HBV reactivation, indicating the potential benefit of anti\u2010HBV prophylaxis treatment in this group of patients.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70186","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T13:04:28Z","timestamp":1759583068000},"page":"1599-1607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antiviral prophylaxis for hepatitis B virus reactivation in T\u2010cell lymphoma patients with resolved hepatitis B virus infection"],"prefix":"10.1002","volume":"158","author":[{"given":"Liyun","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center of Cancer Medicines Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-6292","authenticated-orcid":false,"given":"Shenrui","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center of Cancer Medicines Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center of Cancer Medicines Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Oncology Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center of Cancer Medicines Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center of Cancer Medicines Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center of Cancer Medicines Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center of Cancer Medicines Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center of Cancer Medicines Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center of Cancer Medicines Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center of Cancer Medicines Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5447-3282","authenticated-orcid":false,"given":"Qingqing","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center of Cancer Medicines Sun Yat\u2010sen University Cancer Center  Guangzhou People's Republic of China"},{"name":"Department of Hematology Sun Yat\u2010sen University Cancer Center Gansu Hospital  Lanzhou People's Republic of 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