{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:54:39Z","timestamp":1789707279488,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As the first vaccinated cohorts are gradually becoming eligible for cervical cancer screening (CCS), changes in the distribution of high\u2010risk human papillomavirus (hrHPV) infection and associated disease endpoints are expected to occur. We aimed to describe the clinical outcomes of the Regional CCS Program of the North of Portugal in the latest years and to estimate the impact of different hrHPV genotypes on the occurrence of cervical neoplasia. Secondary data collected from the Regional CCS Program of the North of Portugal between January 2019 and December 2024 was used. Descriptive analysis was performed, and the proportion of high\u2010grade squamous intraepithelial lesion (\u2265HSIL) attributable to different hrHPV genotypes was estimated. Between January 2022 and December 2024, the prevalence of hrHPV infection was 14.1%, and multiple infections accounted for 28.4% of the cases. Overall, the most prevalent genotypes were HPV\u201068 (16.6%), HPV\u201052 (14.5%), and HPV\u201031 (13.3%). Among the samples that underwent cytological analysis, 14.8% were atypical squamous cells of undetermined significance, 7.2% were low\u2010grade squamous intraepithelial lesion, and 3.9% were \u2265HSIL. Between 2019 and 2024, there was a decrease in the prevalence of the hrHPV genotypes included in the quadrivalent vaccine (17.5%\u201311.4%), especially in the youngest females, who also experienced a decrease in the frequency of \u2265HSIL (6.0%\u20132.4%). The proportion of \u2265HSIL attributable to these hrHPV types decreased from 38.5% to 23.5% in the youngest females, and no significant variations were found for the remaining. This study highlights the considerable reduction of the prevalence of both hrHPV infection and associated cervical abnormalities among the youngest and presumably vaccinated cohorts.<\/jats:p>","DOI":"10.1002\/ijc.70196","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:19:56Z","timestamp":1762201196000},"page":"1577-1587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The cervical cancer screening program in the North of Portugal: Outcomes after nearly two decades of coexistence with the human papillomavirus vaccine"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1868-7527","authenticated-orcid":false,"given":"Patr\u00edcia","family":"S\u00e1","sequence":"first","affiliation":[{"name":"Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto) Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca)  Porto Portugal"},{"name":"Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI\u2010IPOP)\/CI\u2010IPOP@RISE (Health Research Network) Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca)  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Henrique","sequence":"additional","affiliation":[{"name":"Department of Pathology, Portuguese Oncology Institute of Porto (IPO Porto) Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca)  Porto Portugal"},{"name":"Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI\u2010IPOP)\/CI\u2010IPOP@RISE (Health Research Network) Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca)  Porto Portugal"},{"name":"Department of Pathology and Molecular Immunology, ICBAS\u2010School of Medicine &amp; Biomedical Sciences University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-1430","authenticated-orcid":false,"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[{"name":"Department of Public Health and Forensic Sciences, and Medical Education, Faculty of Medicine University of Porto  Porto Portugal"},{"name":"Associate Laboratory for Integrative and Translational Research in Population Health (ITR)\u2014Epidemiology Research Unit (EPIUnit), Institute of Public Health University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33628"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2024.108165"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pky045"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096\u20109896(199909)189:1<12::AID\u2010PATH431>3.0.CO;2\u2010F"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.4.244"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30716"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01097\u20103"},{"key":"e_1_2_10_10_1","first-page":"20788","volume-title":"de 21 de setembro. Di\u00e1rio da Rep\u00fablica no 183\/2017, S\u00e9rie II de 2017\u201009\u201021","author":"Despacho n.o 8254\/2017","year":"2017"},{"key":"e_1_2_10_11_1","volume-title":"de 20 de mar\u00e7o. Di\u00e1rio da Rep\u00fablica no 57\/2008, S\u00e9rie II de 2008\u201003\u201020","author":"Despacho n.o 8378\/2008","year":"2008"},{"key":"e_1_2_10_12_1","first-page":"26093","volume-title":"de 19 de agosto. Di\u00e1rio da Rep\u00fablica no 159\/2016, S\u00e9rie II de 2016\u201008\u201019","author":"Despacho n.o 10441\/2016","year":"2016"},{"key":"e_1_2_10_13_1","first-page":"30","volume-title":"de 30 de dezembro. Di\u00e1rio da Rep\u00fablica No 250\/2019, S\u00e9rie II de 2019\u201012\u201030","author":"Despacho n.o 12434\/2019","year":"2019"},{"key":"e_1_2_10_14_1","unstructured":"Dire\u00e7\u00e3o\u2010Geral da Sa\u00fade.Norma 09\/2024 de 17 de outubro de 2024.2024. Accessed Feb 21 2025.https:\/\/www.dgs.pt\/normas-orientacoes-e-informacoes\/normas-e-circulares-normativas\/norma-092024-de-17102024-programa-de-rastreio-de-base-populacional-do-cancro-do-colo-do-utero1.aspx"},{"key":"e_1_2_10_15_1","unstructured":"IARC.IARC monographs on the evaluation of carcinogenic risks to humans: human papillomaviruses.2007. Accessed Mar 3 2025.https:\/\/publications.iarc.who.int\/Book\u2010And\u2010Report\u2010Series\/Iarc\u2010Monographs\u2010On\u2010The\u2010Identification\u2010Of\u2010Carcinogenic\u2010Hazards\u2010To\u2010Humans\/Human\u2010Papillomaviruses\u20102007"},{"key":"e_1_2_10_16_1","unstructured":"Dire\u00e7\u00e3o\u2010Geral da Sa\u00fade.Avalia\u00e7\u00e3o E Monitoriza\u00e7\u00e3o Dos Rastreios Oncol\u00f3gicos Organizados de Base Populacional 2022 \u2013 Portugal.2023."},{"key":"e_1_2_10_17_1","first-page":"13(2)","volume-title":"de 18 de mar\u00e7o. Di\u00e1rio da Rep\u00fablica no 55\/2020, 3\u00b0 Suplemento, S\u00e9rie I de 2020\u201003\u201018","author":"Decreto do Presidente da Rep\u00fablica n.o 14\u2010A\/2020","year":"2020"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pvr.2019.100179"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28414"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e31821dd3b2"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e35736"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20100691.2010.03387.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2024.04.020"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e318280f26e"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12243"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cej.0000178079.29533.1e"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2022.2129615"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2023.2287135"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2023.0064"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.24340"},{"key":"e_1_2_10_31_1","unstructured":"daSa\u00fadeD\u2010G.Boletim Vacina\u00e7\u00e3o | PNV \u2013 Avalia\u00e7\u00e3o 2015.2016. Accessed Feb 21 2025.https:\/\/www.dgs.pt\/documentos-e-publicacoes\/boletim-vacinacao-n-10-abril-de-2016-pdf.aspx"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn044"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70196","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:23:42Z","timestamp":1787761422000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,3,15]]}},"alternative-id":["10.1002\/ijc.70196"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70196","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]},"assertion":[{"value":"2025-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}