{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:18:27Z","timestamp":1787764707435,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    VEGF\u2010driven angiogenesis fuels epithelial ovarian cancer progression, ascites, and poor prognosis. Current anti\u2010VEGF\/chemotherapy combinations provide only transient benefits with notable toxicity. HEBERSaVax, a first\u2010in\u2010class VEGF\u2010targeting immunotherapy, combines recombinant VEGF\u2010A\n                    <jats:sub>121<\/jats:sub>\n                    with proprietary adjuvants to generate dual anti\u2010tumor effects: (1) neutralizing VEGF signaling via antibodies and (2) eliminating VEGF\u2010producing cells through cytotoxic T\u2010cell responses. We present results from the multicenter, open\u2010label CENTAURO 4 phase 2 trial evaluating two formulations of HEBERSaVax combined with carboplatin\/paclitaxel in advanced epithelial ovarian cancer patients (unresectable or suboptimal debulked). Forty patients were randomized 1:1 to receive either: Group 1: Standard chemotherapy (carboplatin\/paclitaxel) plus CIGB\u2010247 vaccine (800\u2009\u03bcg antigen with 200\u2009\u03bcg VSSP adjuvant) Group 2: The same chemotherapy regimen plus CIGB\u2010247 (800\u2009\u03bcg antigen with 0.7\u2009mg aluminum phosphate adjuvant). The primary endpoint was progression\u2010free survival. Secondary endpoints included objective response rate, overall survival, safety, and immune response results. HEBERSaVax exhibited excellent safety profiles and comparable immunogenicity with both adjuvant formulations. Vaccination\u2010related adverse events were limited to grade 1\u20132 toxicities. Long\u2010term outcomes showed promising clinical activity, with a median progression\u2010free survival of 18\u2009months and a global median overall survival of 32.82\u2009months at 6\u2010year follow\u2010up. No statistically significant differences emerged between the VSSP and aluminum phosphate adjuvant formulations for either safety or efficacy endpoints. These clinical outcomes and the vaccine's favorable toxicity profile position HEBERSaVax as a promising immunotherapeutic strategy for improving epithelial ovarian cancer management.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70199","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:20:15Z","timestamp":1760620815000},"page":"1628-1639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>HEBERSaVax<\/scp>\n                    immunotherapy combined with first\u2010line chemotherapy in advanced ovarian cancer: Phase\n                    <scp>II CENTAURO<\/scp>\n                    \u20104 trial results"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1857-4219","authenticated-orcid":false,"given":"Francisco","family":"Hern\u00e1ndez\u2010Bernal","sequence":"first","affiliation":[{"name":"Center for Genetic Engineering and Biotechnology (CIGB)  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katty\u2010Hind Selman\u2010Housein","family":"Bernal","sequence":"additional","affiliation":[{"name":"Center of Medical and Surgical Research  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Bequet\u2010Romero","sequence":"additional","affiliation":[{"name":"Center for Genetic Engineering and Biotechnology (CIGB)  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenima","family":"Mart\u00edn\u2010Bauta","sequence":"additional","affiliation":[{"name":"Center for Genetic Engineering and Biotechnology (CIGB)  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karem M.","family":"Catas\u00fas\u2010\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Center for Genetic Engineering and Biotechnology (CIGB)  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihosvanny E.","family":"Carre\u00f1o\u2010Rolando","sequence":"additional","affiliation":[{"name":"\u201cFaustino Perez\u201d Clinical Surgical Hospital  Matanzas Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Rodr\u00edguez\u2010Reinoso","sequence":"additional","affiliation":[{"name":"Center for Genetic Engineering and Biotechnology (CIGB)  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yania L. 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