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This review included cohort studies of adult patients with cancer diagnosed with Coronavirus disease 2019 (COVID\u201019). We searched MEDLINE and Embase for data from December 2019 to June 2025, and Cochrane Central Libraries and other databases for data to July 2023. Two independent reviewers screened references, extracted data, and assessed bias risk. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to evaluate the certainty of the evidence and present the relative and absolute effect sizes. Fifty\u2010two prognostic factors were identified from 92 included studies. These included sociodemographic variables, comorbidities, cancer\u2010related characteristics, COVID\u201019\u2010related clinical features, and laboratory results. We found high certainty associations between an increased risk of death and male sex (absolute risk [AR]\u2009=\u20093.7%, 95% confidence interval [CI]\u2009=\u20092.1% to 5.8%), high Charlson Comorbidity Index (AR\u2009=\u20098.8%, 95% CI\u2009=\u20097.2%\u201310.6%), low performance status (AR\u2009=\u200914.7%, 95% CI\u2009=\u200911.2%\u201318.7%), immunosuppression (AR\u2009=\u200914.5%, 95% CI\u2009=\u20097.3%\u201324.6%), kidney disease (AR\u2009=\u20099.2%, 95% CI\u2009=\u20094.9%\u201314.7%), and lung cancer (AR\u2009=\u20097.2%, 95% CI\u2009=\u20093.5%\u201312.0%). Hypoxia, high creatinine, high C\u2010reactive protein, high D\u2010dimer, low hemoglobin, low lymphocytes, high procalcitonin, and high white blood cell counts were also associated with increased mortality with high certainty. This comprehensive GRADE\u2010based systematic review provides healthcare providers with evidence\u2010based prognostic factors to predict outcomes, counsel patients, and guide treatment decisions for cancer patients with COVID\u201019. The findings offer crucial insights for managing this vulnerable population during the pandemic.<\/jats:p>","DOI":"10.1002\/ijc.70202","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T04:21:37Z","timestamp":1760761297000},"page":"1640-1653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic factors of mortality in patients with cancer infected with\n                    <scp>COVID<\/scp>\n                    \u201019: A systematic review and meta\u2010analysis using the\n                    <scp>GRADE<\/scp>\n                    approach"],"prefix":"10.1002","volume":"158","author":[{"given":"Eu Chang","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Urology, Chonnam National University Medical School Chonnam National University Hwasun Hospital  Hwasun Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun 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