{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:08:19Z","timestamp":1788433699950,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["232880"],"award-info":[{"award-number":["232880"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Studies on mantle cell lymphoma (MCL) emphasize that patients with progression of disease (POD) \u226424\u2009months have inferior prognosis compared to patients with later POD. This population\u2010based study assessed the impact of POD on overall survival (OS) by timing of progression and first\u2010line treatment. A total of 1186 MCL patients diagnosed 2006\u20132018 were identified in the Swedish lymphoma register. POD was defined as progressive disease after first\u2010line treatment or relapse following initial response. Hazard ratios (HRs) with 95% confidence intervals (CIs), comparing all\u2010cause mortality among patients with and without POD, were estimated with Cox regression. An illness\u2010death model was used to quantify the impact of timing of progression on OS, conditional on the timepoint of POD\/PF (progression\u2010free). Patients were followed for up to 10\u2009years following treatment (median 3.7\u2009years). BR, Nordic MCL2, and R\u2010CHOP\/R\u2010CHOP\u2010like treatment were administered to 33%, 30%, and 14% of patients. Almost half (48%,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009572) of patients experienced POD, with consequently higher mortality, regardless of timing and treatment (adjusted HR\u2009=\u20097.56, 95% CI: 6.32\u20139.05). Importantly, even for patients with POD after 6\u201310\u2009years, mortality was more than two\u2010fold increased (HR\u2009=\u20092.67, 95% CI: 1.05\u20136.79). On the absolute scale, a survival difference persisted for progression occurring up to 9\u2009years after primary treatment. Especially early but also late progression (well beyond the 24\u2010month mark) has a large negative impact on survival in MCL. These results highlight the need for improved first\u2010line, including maintenance therapies to sustain remission and optimize outcomes for MCL patients.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70220","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:52:03Z","timestamp":1762332723000},"page":"1836-1845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disease progression more than 6\u2009years after treatment impacts overall survival in mantle cell lymphoma"],"prefix":"10.1002","volume":"158","author":[{"given":"Sara","family":"Ekberg","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Red Door Analytics AB  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6158-3041","authenticated-orcid":false,"given":"Ingrid","family":"Glimelius","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Immunology, Genetics and Pathology, Cancer Precision Medicine Uppsala University and Uppsala Akademiska Hospital  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Albertsson\u2010Lindblad","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Clinical Sciences Lund Sk\u00e5ne University Hospital, Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin E.","family":"Smedby","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Jerkeman","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Clinical Sciences Lund Sk\u00e5ne University Hospital, Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.27980"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15643"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000510"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010020\u201001013\u20103"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010025\u201001241\u20109"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004765"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023009804"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010019\u20100209\u20105"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023525"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/1651\u2010226X.2024.40431"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/hs9.0000000000000928"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102008\u201003\u2010147025"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/hs9.0000000000000838"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010024\u201001204\u20106"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2201817"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01586"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(24)00732\u20100"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(24)00682\u2010X"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.113403"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)00184\u20103"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102024\u2010212973"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010017\u20100316\u20101"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701769"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012424"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02370"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023021306"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70220","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:14:51Z","timestamp":1787760891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,4,1]]}},"alternative-id":["10.1002\/ijc.70220"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70220","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,5]]},"assertion":[{"value":"2025-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}