{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:34:34Z","timestamp":1787762074002,"version":"build-2784847793"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005026","name":"Stichting Tegen Kanker","doi-asserted-by":"publisher","award":["2023\u2010003"],"award-info":[{"award-number":["2023\u2010003"]}],"id":[{"id":"10.13039\/501100005026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Despite demographic and socio\u2010economic similarities between the Netherlands and Belgium, differences in survival for patients with esophageal and gastric cancer between the two countries exist. This population\u2010based study investigated these survival differences with the aim of identifying explaining factors. We analyzed data from the Netherlands Cancer Registry (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200926,980) and the Belgian Cancer Registry (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200915,097) for patients diagnosed with esophageal or gastric cancer between 2010 and 2016. Survival differences were examined using relative survival, stratified for tumor location and stage. Factors that potentially mediated the survival differences were tested via multivariable excess hazard models controlling for baseline population mortalities. Five\u2010year relative survival probability was significantly lower for patients from the Netherlands with esophageal cancer (EC) or gastric cancer (GC) (EC: 21% (20%\u201322%), GC: 20% (19%\u201321%)) compared to Belgian patients (EC: 24% (23%\u201325%), GC: 27% (25%\u201329%)). Across tumor stages, relative survival of patients with esophageal and gastric cancer was lower among patients from the Netherlands. Multivariable excess hazard modeling showed that survival differences of patients with stage IV disease disappeared when adjusting for treatment. This was not observed among patients with stage I\u2013III gastric cancer, where survival differences remained after adjustment for treatment. Survival of patients with esophageal cancer and gastric cancer is generally higher in Belgium. For patients with stage IV disease, this difference can most likely be attributed to differences in treatment. Although treatment explains part of the survival differences for patients with curable disease, other causes remain largely unknown.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70225","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:15:57Z","timestamp":1763550957000},"page":"1868-1880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment and survival of patients with esophageal and gastric cancer in the Netherlands and Belgium: A population\u2010based comparison"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8162-0804","authenticated-orcid":false,"given":"Benthe H.","family":"Doeve","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam Cancer Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Laboratory of Experimental Oncology and Radiobiology, Cancer Center Amsterdam Amsterdam UMC and University of Amsterdam  Amsterdam The Netherlands"},{"name":"Oncode Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7035-7863","authenticated-orcid":false,"given":"Steven C.","family":"Kuijper","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam Cancer Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Department of Research &amp; Development Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1104-1839","authenticated-orcid":false,"given":"Geert","family":"Silversmit","sequence":"additional","affiliation":[{"name":"Belgian Cancer Registry  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien","family":"van Walle","sequence":"additional","affiliation":[{"name":"Belgian Cancer Registry  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Nafteux","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camiel","family":"Rosman","sequence":"additional","affiliation":[{"name":"Department of Surgery Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0677-888X","authenticated-orcid":false,"given":"Pauline A. J.","family":"Vissers","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Oncology and Radiobiology, Cancer Center Amsterdam Amsterdam UMC and University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Surgery Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Jeene","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Radiotherapiegroep  Deventer The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurens V.","family":"Beerepoot","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Elisabeth Tweesteden Ziekenhuis  Tilburg The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Derks","sequence":"additional","affiliation":[{"name":"Cancer Center Amsterdam Cancer Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Department of Research &amp; Development Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht The Netherlands"},{"name":"Department of Medical Oncology Amsterdam UMC, Free University  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amine","family":"Karimi","sequence":"additional","affiliation":[{"name":"Department of Surgery Jessa Ziekenhuis  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6627-3229","authenticated-orcid":false,"given":"Maarten F.","family":"Bijlsma","sequence":"additional","affiliation":[{"name":"Cancer Center Amsterdam Cancer Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Laboratory of Experimental Oncology and Radiobiology, Cancer Center Amsterdam Amsterdam UMC and University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke W. 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