{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:53:20Z","timestamp":1773017600768,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Patients with metastatic uveal melanoma (UM) have a poor prognosis. While long\u2010term survival data in cutaneous melanoma (CM) are promising, such data are lacking in UM and long\u2010term survivors are rare. In cases of metastases, the liver is affected in 90% of cases and is the main determinant of life expectancy. Immune checkpoint inhibitors (ICI) are less effective in UM than in CM. Therefore, liver\u2010directed therapies are of high relevance. We evaluated a large cohort of UM patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009167) who had developed liver metastases between 2005 and 2021. We focused on patients who survived 3\u2009years or more from the initial diagnosis of liver metastases and precisely characterized this cohort with regard to systemic therapies (ST) and liver\u2010specific procedures applied. The last follow\u2010up (FU) date was October 31, 2024. We identified 33 long\u2010term survivors, representing 20% of the total cohort. Most patients had additional extrahepatic metastases (23\/33; 70%), while 10 patients had liver metastases only. First\u2010line treatment in the metastatic setting consisted of liver\u2010directed therapies in most of the cases (27\/33; 82%). 90% of the patients had received at least one liver\u2010specific procedure at any time point during FU and 85% had received ICI at any time point. Response evaluation revealed a high percentage of patients with disease control (DC) after the first ST (17\/27; 63%) or first liver\u2010specific therapy (27\/29; 93%), respectively. Notably, all patients with chemosaturation as their first liver\u2010specific procedure achieved DC. Further data are needed on the combination of liver\u2010directed therapy and ST, such as ICI or Tebentafusp.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70246","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T10:57:55Z","timestamp":1762858675000},"page":"2179-2185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of long\u2010term survivors with liver metastases from uveal melanoma diagnosed between 2005 and 2021"],"prefix":"10.1002","volume":"158","author":[{"given":"Jona","family":"Laukhuf","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Wiens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Gr\u00f6zinger","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital Tuebingen  Tuebingen Germany"},{"name":"Center of Radiology, Minimally Invasive Therapies and Nuclear Medicine, SLK\u2010Kliniken Heilbronn Academic Hospital of Ruprecht\u2010Karls\u2010University  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Dittmann","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Clinical Molecular Imaging Eberhard Karls University of Tuebingen  Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolin","family":"Thiel","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thorax Surgery Oberschwabenklinik  Ravensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Leiter","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Amaral","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Nanz","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Flatz","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Reitmajer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6185-4945","authenticated-orcid":false,"given":"Andrea","family":"Forschner","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.08.2330"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.21.02229"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2407417"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/17588359241273020"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238\u2010024\u201001497\u20108"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.07.017"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000624"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304753"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34927"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010024\u201015293\u2010x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010024\u201016039\u20105"},{"key":"e_1_2_13_13_1","first-page":"2495","article-title":"New 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