{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:04:47Z","timestamp":1773007487046,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Epstein\u2013Barr virus (EBV) infection is frequently observed in angioimmunoblastic T\u2010cell lymphoma (AITL), yet its prognostic and therapeutic implications remain unclear. This multicenter real\u2010world study analyzed 155 newly diagnosed AITL patients (117 EBV\u2010encoded RNA\u2010positive [EBER+] and 38 EBER\u2010negative [EBER\u2212]) from Chinese institutions between 2012 and 2022. EBER+ cases demonstrated significantly higher Ki67 proliferation indices and CD30 expression compared to EBER\u2212 cases (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.013 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.045, respectively). While no survival difference was observed between EBER+ and EBER\u2212 groups (overall survival [OS]\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.16; progression\u2010free survival [PFS]\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.43), chidamide\u2010combined chemotherapy significantly improved outcomes exclusively in EBER+ patients (OS\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.014; PFS\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0018) with no benefit seen in EBER\u2212 cases (OS\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.98; PFS\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.83). Multivariate analysis identified distinct risk factors by EBV status. Older age (\u226560), thrombocytopenia (&lt;150\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L) and nasopharyngeal involvement independently predicted poor prognosis in EBER+ patients, whereas B symptoms were prognostic in EBER\u2212 cases. These findings suggest that EBER+ and EBER\u2212 AITL may represent distinct disease entities. EBV infection appears to influence disease progression and prognosis in EBER\u2010positive patients, whereas EBER\u2010negative cases more closely align with the disease characteristics observed in other peripheral T\u2010cell lymphomas. The results suggest that stratifying patients by EBV status is crucial for optimizing AITL clinical management.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70251","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:09:36Z","timestamp":1763640576000},"page":"2380-2391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The efficacy and survival impact of chidamide on angioimmunoblastic T\u2010cell lymphoma based on Epstein\u2010Barr virus stratification in the real world: A multicenter study"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7403-2676","authenticated-orcid":false,"given":"Xuemei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Hematology The Affiliated Hospital of Southwest Medical University  Luzhou 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