{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:13:16Z","timestamp":1789427596212,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We assessed long\u2010term trends in cancer incidence among people with HIV (PWH) in France between 1997 and 2018, focusing on AIDS\u2010defining cancers (ADC) (Kaposi's sarcoma, non\u2010Hodgkin's lymphoma, and cervical cancer), three virus\u2010related non\u2010AIDS\u2010defining cancers (Hodgkin lymphoma, liver, and anal cancer), and four virus\u2010unrelated cancers (lung, colorectal, prostate, and breast cancer). Using data from the ANRS CO4\u2010French Hospital Database on HIV and cancer registries in the general population, we calculated age\u2010standardized incidence rates and standardized incidence ratios (SIRs) across four time periods. Special attention was given to PWH with controlled viral load and restored CD4 during 2008\u20132018. Among 154,733 individuals contributing nearly 2 million person\u2010years, 9572 cancers were diagnosed. Incidence rates of ADC and virus\u2010related non\u2010ADC declined over time but remained significantly higher than in the general population, with SIRs ranging from 3 to 420, even in recent years. Rates of prostate and colorectal cancers increased overtime, while breast cancer incidence remained stable. For these three cancers, the relative risk compared to the general population remained close to 1. In PWH with CD4\u2009\u2265\u2009500\/mm\n                    <jats:sup>3<\/jats:sup>\n                    for at least 2\u2009years and with recent viral load \u226450\u2009copies\/mL, risks of virus\u2010related cancers (KS, NHL, HL, liver, and anal cancer) remained significantly higher relative to the general population, albeit to a lesser extent than in PWH overall, while risks of lung and cervical cancers were similar. Over 20\u2009years, the incidence of all virus\u2010related cancers continued to fall but in the most recent period, the risks still remained higher than in the general population.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70253","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:30:04Z","timestamp":1763641804000},"page":"2298-2308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cancer risks and trends between 1997 and 2018, and effects of restored immunity in people living with\n                    <scp>HIV<\/scp>\n                    : Results from the\n                    <scp>ANRS CO4<\/scp>\n                    French hospital database on\n                    <scp>HIV<\/scp>"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4816-4261","authenticated-orcid":false,"given":"Sophie","family":"Grabar","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Lakrout","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Potard","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1410-5172","authenticated-orcid":false,"given":"Aur\u00e9lien","family":"Belot","sequence":"additional","affiliation":[{"name":"Inequalities in Cancer Outcomes Network (ICON), Department of Health Services Research and Policy, Faculty of Public Health and Policy London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2446-2923","authenticated-orcid":false,"given":"Jacques","family":"Cadranel","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Tenon, Service de Pneumologie et Oncologie Thoracique, GRCO4 Theranoscan Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Jacomet","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Clermont\u2010Ferrand University Hospital  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Katlama","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique  Paris France"},{"name":"AP\u2010HP, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re Service de Maladies Infectieuses et Tropicales  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esa\u00efe","family":"Marshall","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lambotte","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Saclay, AP\u2010HP, Service de M\u00e9decine Interne Immunologie Clinique H\u00f4pital de Bic\u00eatre, Inserm  Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Palich","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique  Paris France"},{"name":"Infectious Diseases Department, H\u00f4tel\u2010Dieu Hospital, AP\u2010HP Paris Cit\u00e9 University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Ronot\u2010Bregigeon","sequence":"additional","affiliation":[{"name":"APHM, H\u00f4pital Sainte\u2010Marguerite Aix\u2010Marseille Universit\u00e9  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Spano","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, AP\u2010HP  Paris France"},{"name":"AP\u2010HP, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re Service 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