{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:04:54Z","timestamp":1773007494965,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J011254"],"award-info":[{"award-number":["2023J011254"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The clinical features, treatment efficacy, and prognostic differences in melanoma patients with cavity carcinomatosis, which is of rare occurrence, are still unclear. A retrospective analysis was conducted on melanoma patients with cavity carcinomatosis treated at Fujian Cancer Hospital from 2007 to 2023, with follow\u2010up ending in March 2024. The results showed that among 1430 melanoma patients, 79 had cavity carcinomatosis (5.5%). Median time to cavity carcinomatosis was 6.53\u2009months (interquartile range: 0.23\u201326.20). The survival after melanoma cavity carcinomatosis was 5.23\u2009months (95% CI: 4.39\u20136.07). Post\u2010cavity carcinomatosis survival improved to 6.30\u2009months with treatment, versus 1.13\u2009months without (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.001). Anti\u2010BRAF treatment did not outperform with only 4.83\u2009months of progression\u2010free survival, and the objective response rate was 14.29%. The curative effect of chemotherapy and immunotherapy on BRAF wild\u2010type patients was similar. LDH levels strongly correlated with cavity carcinomatosis survival; patients with LDH\u2009\u2264\u2009ULN and ULN\u2009&lt;\u2009LDH\u2009\u2264\u20092.5ULN lived longer than those with LDH\u2009&gt;\u20092.5ULN (6.77 vs. 5.13 vs. 2.67\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.008). This indicated that melanoma with cavity carcinomatosis should be considered a distinct subtype that signifies a high mortality rate. Continuous anti\u2010tumor therapy can still improve survival despite the lack of standout treatments after onset. Serum LDH levels hold the potential to serve as a crucial survival predictor.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70254","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:17:37Z","timestamp":1763464657000},"page":"2418-2428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics, treatment response, and survival outcomes in melanoma patients with cavity carcinomatosis: A retrospective analysis"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-1526","authenticated-orcid":false,"given":"Zhongqiao","family":"Lin","sequence":"first","affiliation":[{"name":"Phase I Clinical Trial Ward, Clinical Oncology School of Fujian Medical University Fujian Cancer Hospital, NHC Key Laboratory of Cancer Metabolism  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Clinical Oncology School of Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyang","family":"Huang","sequence":"additional","affiliation":[{"name":"Fuzhou University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9881-2976","authenticated-orcid":false,"given":"Lizhu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Clinical Oncology School of Fujian Medical University Fujian Cancer Hospital, NHC Key Laboratory of Cancer Metabolism  Fuzhou China"},{"name":"Cancer Bio\u2010Immunotherapy Center, Clinical Oncology School of Fujian Medical University Fujian Cancer Hospital, NHC Key Laboratory of Cancer Metabolism  Fuzhou 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