{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:05:00Z","timestamp":1773007500820,"version":"3.50.1"},"reference-count":108,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute leukemia is the most common type of cancer in children; however, the etiology is poorly understood. The objective of this review was to summarize the current evidence of the role of perinatal factors in the development of acute leukemia. All epidemiological studies published up to October 2023 that evaluated perinatal risk factors for childhood acute leukemia were identified using a multi\u2010tiered approach in two electronic databases (PubMed and Web of Science), without restriction on publication year or language. A total of 85 studies (13 prospective cohort studies, 62 case\u2013control studies, and 10 pooled analyses) were included. We combined the published risk estimates in a meta\u2010analysis, using the Generic Inverse Variance method. An increased risk of acute leukemia and the lymphoblastic subtype (ALL) was associated with high birth weight (&gt;4000\u2009g) (odds ratio [OR]\u2009=\u20091.35; 95% confidence interval [95% CI] 1.20\u20131.53 and OR\u2009=\u20091.21; 95% CI 1.08\u20131.34, respectively), maternal history of abortion (OR\u2009=\u20091.27; 95% CI 1.12\u20131.43 and OR\u2009=\u20091.24; 95% CI 1.08\u20131.43, respectively), and maternal diabetes (OR\u2009=\u20091.30; 95% CI 1.14\u20131.48 and OR\u2009=\u20091.32; 95% CI 1.16\u20131.50, respectively). In addition, an increased risk for ALL was also associated with maternal hypertension (OR\u2009=\u20091.21; 95% CI 1.06\u20131.38) and cesarean section (OR\u2009=\u20091.10; 95% CI 1.05\u20131.16). Our review suggests a potential role for perinatal factors in the development of acute leukemia in children. These findings indicate potential avenues for developing cost\u2010effective prevention strategies applicable at the population level, while the mechanism of action is investigated.<\/jats:p>","DOI":"10.1002\/ijc.70256","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:12:13Z","timestamp":1763964733000},"page":"2392-2417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of the perinatal experience on the risk of acute leukemia in childhood or adolescence: Systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-7138","authenticated-orcid":false,"given":"Jessica","family":"Blanco\u2010Lopez","sequence":"first","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambroise Kouame","family":"Kintossou","sequence":"additional","affiliation":[{"name":"Biobank Pasteur Institute of C\u00f4te d'Ivoire  Abidjan C\u00f4te d'Ivoire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiny","family":"Manohar","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Iguacel","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Zaragoza  Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Pisanu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Section of Microbiology and Virology University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Choma Bettega","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Nutrition Federal University of Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Steliarova\u2010Foucher","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciska","family":"Sierens","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc J.","family":"Gunter","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Public Health Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena J.","family":"Ladas","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology\/Stem Cell Transplantation, Department of Pediatrics Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald D.","family":"Barr","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pathology and Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Van Herck","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zisis","family":"Kozlakidis","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Huybrechts","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(17)30186\u20109"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010024\u201002452\u2010y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)33326\u20103"},{"key":"e_1_2_11_5_1","unstructured":"CureAll framework: WHO Global Initiative for Childhood Cancer. Increasing access advancing quality saving lives. Geneva: World Health Organization; 2021. Licence: CC BY\u2010NC\u2010SA 3.0 IGO; WHO Geneva; 2021.https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/igo\/"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9023"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2012.01.007"},{"key":"e_1_2_11_8_1","first-page":"1","volume-title":"Cancer Epidemiology: Principles and Methods","author":"Santos Silva I","year":"1999"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106947\u201010\u201029"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470712184"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6785.1136"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181a5a332"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2019.101581"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(16)00002\u20108"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu265"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12193"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31635"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2019.01.022"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010018\u20100402\u2010z"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.11.017"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25593"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29172"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010015\u20100063\u20100"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S147188"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.546915"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32905"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16335"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603173"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm065"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.12667"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600012"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30188"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.1057.13.6"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwz118"},{"issue":"116","key":"e_1_2_11_36_1","first-page":"2624","article-title":"Breast feeding and its association with childhood leukemia: a retrospective casecontrol study among children attending King Abdulaziz University Hospital in Jeddah, Saudi Arabia","volume":"25","author":"Abudaowd O","year":"2021","journal-title":"Med Sci"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010023\u201001745\u20104"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2015.1052867"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1317"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010011\u20109882\u20109"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12662"},{"issue":"5","key":"e_1_2_11_42_1","article-title":"Parental exposure to carcinogens and risk for childhood acute lymphoblastic leukemia, Colombia, 2000\u20102005","volume":"8","author":"Castro\u2010Jimenez MA","year":"2011","journal-title":"Prev Chronic Dis"},{"issue":"5","key":"e_1_2_11_43_1","first-page":"441","article-title":"Prenatal and neonatal risk factors for childhood myeloid leukemia","volume":"4","author":"Cnattingius S","year":"1995","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.12.908"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010016\u20100807\u20105"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2017.06.010"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690548"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/30.6.1428"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010016\u20102689\u2010z"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201013\u20101098"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/19932820.2018.1508273"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.14423\/smj.0000000000000873"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh287"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010022\u201001961\u2010w"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1495"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1414"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2020.101851"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102008\u20101043877"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12207"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910915)68:6<1351::AID-CNCR2820680627>3.0.CO;2-J"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj336"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605957"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010021\u201001423\u20103"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010005\u20100356\u20109"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201017\u20100778"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690609"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10084"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6606046"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1019555912243"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2012.08.002"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech\u20102014\u2010204975"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2023.102472"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010015\u20100593\u20105"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1013986809917"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-001-0906-4"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603388"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.541"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201022\u20100664"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2022.102308"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2019.20.8.2477"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010010\u20101139\u20101"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.7.603"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.399"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.11.006"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010008\u20109199\u20105"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.4.631"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010006\u20100401\u2010z"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010007\u20109011\u2010y"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32757"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.20.1765"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000151"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010017\u20103681\u2010y"},{"issue":"6","key":"e_1_2_11_93_1","first-page":"457","article-title":"Risk factors for childhood acute non\u2010lymphocytic leukemia: an association with maternal alcohol consumption during pregnancy?","volume":"3","author":"Duijn C","year":"1994","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/14.4.555"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010015\u20101425\u20104"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201020\u20101406"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950401)75:7<1718::AID-CNCR2820750725>3.0.CO;2-G"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010015\u20100089\u20103"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/sageke.2003.8.pe4"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20075428"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.10.046"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010018\u20100015\u20106"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519\u2010020\u201000338\u20104"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.092585"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.5.1389"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2017.1396056"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2022.106924"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171650"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70256","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70256","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:00:18Z","timestamp":1773000018000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,23]]},"references-count":108,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1002\/ijc.70256"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70256","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,23]]},"assertion":[{"value":"2024-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}