{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:26:27Z","timestamp":1788791187388,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sarcomas frequently affect adolescent girls and young women, for whom future fertility is a critical concern. The urgency of initiating treatment\u2014due to rapid tumor progression and the need for extensive diagnostic evaluation\u2014often limits the window for fertility preservation prior to chemotherapy. However, emerging evidence indicates that gonadotoxicity is variable, and ovarian function may be preserved in a substantial number of cases. This observational cohort study evaluates the feasibility, timing, and clinical relevance of fertility preservation in young women treated for high\u2010grade sarcomas or desmoid tumors at Cochin Hospital, AP\u2010HP (Paris, France), with a focus on long\u2010term ovarian function and reproductive outcomes. Among 59 patients (median age at first oncology consultation, 24.3\u2009years), 13 underwent oocyte or ovarian tissue cryopreservation before or early during treatment. Therapy regimens included alkylating and non\u2010alkylating chemotherapies, radiotherapy, or combinations thereof. At last follow\u2010up, 49 women were alive, and 27 had experienced relapse or progression. Among 26 patients assessed for post\u2010treatment ovarian function (median follow\u2010up 62\u2009months), 77% resumed menstruation, 27% conceived naturally, 78% of those actively attempting pregnancy were naturally successful, and 19% gave birth. No patient used cryopreserved oocytes or ovarian tissue. One patient underwent fertility preservation after therapy. These results suggest that systematic fertility preservation may not be mandatory for all patients and that spontaneous ovarian function recovery is common. The observed pregnancy outcomes underscore the importance of personalized, patient\u2010centered fertility counseling based on tumor characteristics and treatment modalities.<\/jats:p>","DOI":"10.1002\/ijc.70260","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:09:49Z","timestamp":1763550589000},"page":"1178-1183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fertility preservation in women with sarcoma: A real\u2010world experience"],"prefix":"10.1002","volume":"158","author":[{"given":"Guillaume","family":"Beinse","sequence":"first","affiliation":[{"name":"Department of Oncology APHP, Cochin Hospital, University Paris Cit\u00e9  Paris France"},{"name":"University Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-305X","authenticated-orcid":false,"given":"Pascaline","family":"Boudou\u2010Rouquette","sequence":"additional","affiliation":[{"name":"Department of Oncology APHP, Cochin Hospital, University Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixtine","family":"de Percin","sequence":"additional","affiliation":[{"name":"Department of Oncology APHP, Cochin Hospital, University Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fortin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology Clinique Gaston Metivet  Saint Maur des Foss\u00e9s France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Noel","sequence":"additional","affiliation":[{"name":"Department of Oncology APHP, Cochin Hospital, University Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Kreps","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology APHP, Georges Pompidou European Hospital, University Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Sroussi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology APHP, Lariboisi\u00e8re Hospital, University Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Barraud\u2010Lange","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology APHP Center, Cochin Hospital, University Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5252-5800","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Alexandre","sequence":"additional","affiliation":[{"name":"Department of Oncology APHP, Cochin Hospital, University Paris Cit\u00e9  Paris France"},{"name":"University Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Goldwasser","sequence":"additional","affiliation":[{"name":"Department of Oncology APHP, Cochin Hospital, University Paris Cit\u00e9  Paris France"},{"name":"University Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3342-1704","authenticated-orcid":false,"given":"Camille","family":"Tlemsani","sequence":"additional","affiliation":[{"name":"Department of Oncology APHP, Cochin Hospital, University Paris Cit\u00e9  Paris France"},{"name":"University Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8043-7506","authenticated-orcid":false,"given":"Catherine","family":"Poirot","sequence":"additional","affiliation":[{"name":"Department of Hematology Adolescents and Young Adults Unit, Fertility Preservation, APHP, Saint Louis Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045\u20103329\u20102\u201014"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu256"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.07.006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2023.0185"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2024.0057"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010021\u201006069\u20100"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147\u2010016\u20100948\u20102"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.05.013"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO\u201024\u201002782"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez047"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010025\u201002520\u20106"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/03008916211040556"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479\u2010828X.2010.01232.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022024"}],"container-title":["International 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