{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:28:28Z","timestamp":1782552508247,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472774"],"award-info":[{"award-number":["82472774"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3403200"],"award-info":[{"award-number":["2023YFC3403200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303755"],"award-info":[{"award-number":["82303755"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["24NSFSC6778"],"award-info":[{"award-number":["24NSFSC6778"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Advances in cancer management have improved oncologic outcomes, but the extent of these improvements and disparities across demographic and socioeconomic groups over the past two decades remains unclear. We identified patients diagnosed with primary cancer at eight sites (lung and bronchus, liver and intrahepatic bile ducts [IHBD], esophagus, colon, kidney, pancreas, rectum, and stomach) between 2000 and 2019 from the Surveillance, Epidemiology, and End Results (SEER)\u201017 database. Kaplan\u2013Meier curves were used to evaluate cancer\u2010specific survival (CSS) across different diagnostic periods, and Cox proportional hazards models were employed to adjust for confounding factors. We found that CSS for eight cancers improved significantly between 2000 and 2019, but the extent of improvement varied by population characteristics. Elderly patients, unmarried individuals, those with low income, and rural residents showed poorer relative CSS improvement across all eight cancers. Relative CSS improvement differences by sex were present across the eight cancers but remained small. Black patients exhibited less relative CSS improvement than White patients only in pancreatic cancer. Absolute 5\u2010year CSS differences by race (White vs. Black) decreased in six cancers except pancreatic and gastric cancers. In summary, the extent of improvement in CSS for the eight cancers varied by demographic characteristics between 2000 and 2019. Absolute survival differences by age, marital status, income, and place of residence widened for most cancers, while racial differences (White vs. Black) narrowed for most cancers. This provides potential recommendations for further adjustments in medical resources.<\/jats:p>","DOI":"10.1002\/ijc.70262","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T09:24:56Z","timestamp":1764062696000},"page":"2329-2338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Survival improvements in major cancers: Trends and disparities in the United States, 2000\u20132019"],"prefix":"10.1002","volume":"158","author":[{"given":"Yaxiong","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyanling","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0617-9286","authenticated-orcid":false,"given":"Jianzhong","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33587"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31761-X"},{"key":"e_1_2_12_6_1","first-page":"1013","article-title":"Measurement of socioeconomic status in health disparities research","volume":"99","author":"Shavers VL","year":"2007","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2022.100551"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003140"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2024.04.002"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01753-0"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu572"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2014.161"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep29655"},{"key":"e_1_2_12_14_1","unstructured":"Number of Persons by Race and Hispanic Ethnicity for SEER Participants. Accessed March 20 2025.https:\/\/seer.cancer.gov\/registries\/data.html"},{"key":"e_1_2_12_15_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program. SEER*Stat Database: Incidence \u2013 SEER Research Data 17 Registries Nov 2023 Sub (2000\u20132021) \u2013 Linked To County Attributes \u2013 Time Dependent (1990\u20132022) Income\/Rurality 1969\u20132022 Counties National Cancer Institute DCCPS Surveillance Research Program released April 2024 based on the November 2023 submission. Accessed March 20 2025.www.seer.cancer.gov"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.06.007"},{"key":"e_1_2_12_17_1","unstructured":"Policy for Calculating Hispanic Mortality for 1990+ Data. Accessed October 5 2025.https:\/\/seer.cancer.gov\/seerstat\/variables\/mort\/origin_recode_1990"},{"key":"e_1_2_12_18_1","unstructured":"Comparison of SEER Data Products\u2010Variable Availability. Accessed March 20 2025.https:\/\/seer.cancer.gov\/data\/product-comparison.html"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.6489"},{"key":"e_1_2_12_20_1","unstructured":"Household Income in States and Metropolitan Areas: 2022. Accessed March 20 2025.https:\/\/www.census.gov\/library\/publications\/2023\/acs\/acsbr-017.html"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djad031"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/10732748211011956"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253854"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16162923"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.09.029"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt197"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0061"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22939"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq043"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.01.025"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-016-1900-9"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07181-6"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21638"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-71999-8"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-023-00806-2"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-24-0585"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-01038-6"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djad069"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.3_suppl.17"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.07.011"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2012.03.012"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54444-2"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022146518808718"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02537"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2013-203053"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz183"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32073"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.94.10.1675"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31704"},{"key":"e_1_2_12_50_1","unstructured":"SEER Acknowledgment of Treatment Data Limitations. Accessed October 5 2025.https:\/\/seer.cancer.gov\/data-software\/documentation\/seerstat\/nov2023\/treatment-limitations-nov2023.html"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70262","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:59:27Z","timestamp":1772999967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":49,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1002\/ijc.70262"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70262","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"2025-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}