{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:39:40Z","timestamp":1779255580344,"version":"3.51.4"},"reference-count":62,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005366","name":"Universitetet i Oslo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clinical trials have shown that low\u2010dose computed tomography (LDCT) screening reduces lung cancer mortality among selected groups of ever\u2010smokers. Nordic countries have yet to implement lung cancer screening programs in part due to limited evidence on the associated health and economic consequences. This study evaluated the cost\u2010effectiveness of LDCT screening compared with no screening for Norwegian individuals aged 50\u201374\u2009years who ever smoked, using the Dutch\u2013Belgian NELSON screening\u2010eligibility criteria and trial outcomes. In addition, we evaluated the potential need and value of additional research to improve decision\u2010making about LDCT screening implementation. We developed a probabilistic simulation model reflecting the Dutch\u2013Belgian NELSON trial outcomes and Norwegian epidemiological, cost, and health\u2010related quality\u2010of\u2010life data to evaluate long\u2010term (discounted) health and economic consequences from an extended healthcare perspective. Model outputs included sex\u2010stratified clinical and economic outcomes. Cost\u2010effectiveness was summarized using incremental cost\u2010effectiveness ratios (ICERs). Compared with no screening, NELSON\u2010like LDCT screening provided an additional 0.043 quality\u2010adjusted life\u2010years (QALYs) per screened man for an additional $1286, yielding an ICER of $30,672 per QALY gained. For women, screening yielded greater health benefits and therefore a lower ICER (i.e., $22,249 per QALY gained), though there was greater uncertainty around health benefits. Additional analyses indicated potential value in collecting further evidence on screening\u2010related outcomes to reduce decision uncertainty, particularly for women. Given Norwegian benchmarks for good value and achieving similar mortality benefits to the NELSON trial, LDCT lung cancer screening for individuals who ever smoked under \u201cNELSON\u2010like\u201d criteria may be considered cost\u2010effective for both men and women in Norway.<\/jats:p>","DOI":"10.1002\/ijc.70270","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T08:44:46Z","timestamp":1766133886000},"page":"2452-2465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cost\u2010effectiveness of low\u2010dose\n                    <scp>CT<\/scp>\n                    lung cancer screening among individuals that have ever smoked in Norway: A model\u2010based analysis using\n                    <scp>NELSON<\/scp>\n                    trial criteria and outcomes"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0373-5701","authenticated-orcid":false,"given":"Yancy S.","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Health Management and Health Economics University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Kunst","sequence":"additional","affiliation":[{"name":"Centre for Health Economics University of York  York UK"},{"name":"Public Health Modeling Unit Yale University School of Public Health  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e1vid M.","family":"Gy\u0151rbir\u00f3","sequence":"additional","affiliation":[{"name":"Department of Health Management and Health Economics University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivar S\u00f8nb\u00f8","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Department of Health Management and Health Economics University of Oslo  Oslo Norway"},{"name":"Research Unit of General Practice University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trond\u2010Eirik","family":"Strand","sequence":"additional","affiliation":[{"name":"Department of Patient Safety and Quality Oslo University Hospital  Oslo Norway"},{"name":"Department of Community Medicine UiT The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav Toai Duc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Cancer Clinic, Levanger Hospital Nord\u2010Tr\u00f8ndelag Health Trust  Levanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Fotopoulos","sequence":"additional","affiliation":[{"name":"Department of Computer Science University of Crete  Heraklion Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluf Dimitri","family":"R\u00f8e","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Cancer Clinic, Levanger Hospital Nord\u2010Tr\u00f8ndelag Health Trust  Levanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haseem","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging Akershus University Hospital  L\u00f8renskog Norway"},{"name":"Division of Medicine and Laboratory Sciences University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily A.","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Health Management and Health Economics University of Oslo  Oslo Norway"},{"name":"Center for Health Decision Science Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Lung Cancer","author":"World Health Organization","year":"2023"},{"key":"e_1_2_11_3_1","volume-title":"Cancer in Norway 2022 \u2013 Cancer Incidence, Mortality, Survival and Prevalence in Norway","author":"Cancer Registry of Norway","year":"2023"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08433-z"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-5144-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2009.02.012"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102873"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911793"},{"key":"e_1_2_11_10_1","unstructured":"deKoningHJ.Clincial Trials Essential Information\u20144\u2010IN\u2010THE\u2010LUNG\u2010RUN.https:\/\/ec.europa.eu\/research\/participants\/documents\/downloadPublic?documentIds=080166e5ce87cc5f&appId=PPGMS2021."},{"key":"e_1_2_11_11_1","unstructured":"Strengthening the screening of lung cancer in Europe.https:\/\/europeanlung.org\/solace\/"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00026-2023"},{"key":"e_1_2_11_13_1","unstructured":"Cancer Research UK.Lung cancer screening.2024.https:\/\/www.cancerresearchuk.org\/health\u2010professional\/cancer\u2010screening\/lung\u2010cancer\u2010screening"},{"issue":"4","key":"e_1_2_11_14_1","first-page":"281","article-title":"Principles and practice of mass screening for disease","volume":"65","author":"Wilson JM","year":"1968","journal-title":"Bol Oficina Sanit Panam"},{"key":"e_1_2_11_15_1","unstructured":"Norwegian Institute of Public Health.Guidelines for the submission of documentation for single technology assessments (STAs) of medical devices and diagnostic interventions."},{"key":"e_1_2_11_16_1","unstructured":"Norwegian Ministry of Health and Care Services.Report. 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