{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:07:34Z","timestamp":1790312854055,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To assess the effectiveness and safety of 5\u2010aminolevulinic acid\u2010based photodynamic therapy (5\u2010ALA PDT) for cervical low\u2010grade squamous intraepithelial lesions (LSIL) patients with high\u2010risk human papillomavirus (HR\u2010HPV) infection and to investigate independent factors that influence the efficacy of PDT treatment. A retrospective analysis was conducted on 530 patients with pathologically confirmed LSIL and HR\u2010HPV infection, treated between March 2017 and January 2024. All patients underwent 5\u2010ALA PDT at an interval of 7\u201314\u2009days, for a total of 3 to 6 sessions. Follow\u2010ups were conducted 3 and 12 months post\u2010treatment. The efficacy was assessed using HPV genotyping, ThinPrep cytology test (TCT) and colposcopy\u2010directed biopsy. The HPV remission rate was 52.08% at 3\u2009months' follow\u2010up and increased to 69.84% at 12\u2010month follow\u2010up, surpassing the rate at 3\u2010month follow\u2010up (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The LSIL regression rate was 75.85% at 3\u2009months' follow\u2010up and rose to 86.77% at 12\u2010month follow\u2010up, exceeding the rate at 3\u2010months' follow\u2010up (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Multivariate analysis revealed that single HPV infection (OR 2.296 [95%CI 1.550\u20133.402]) was an independent predictor of HPV remission after 5\u2010ALA PDT treatment. Single HPV infection (OR 1.690 [95% CI 1.077\u20132.652]), type III transformation zone (OR 3.094 [95% CI 1.899\u20135.041]), HPV remission after PDT treatment (OR 4.938 [95% CI 3.099\u20137.870]) were independent predictors of LSIL participants receiving total lesion regression after PDT treatment. Adverse reactions were all mild. 5\u2010ALA PDT is an effective and non\u2010invasive therapy for LSIL patients with HR\u2010HPV infection. Identifying predictors of treatment success may optimize patient selection, ultimately improving clinical outcomes.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70273","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T14:20:23Z","timestamp":1765203623000},"page":"2650-2657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of 5\u2010aminolevulinic acid\u2010based photodynamic therapy for cervical low\u2010grade squamous intraepithelial lesions with\n                    <scp>HPV<\/scp>\n                    infections"],"prefix":"10.1002","volume":"158","author":[{"given":"Yuan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubei","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3734-1741","authenticated-orcid":false,"given":"Lihua","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Obstetrics and Gynecology Shanghai Jiading Central Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(13)60022\u20107"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/lgt.0000000000000604"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/lgt.0000000000000525"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.12.112"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2022.102993"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147\u2010023\u201002337\u20107"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1301440"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2020.102172"},{"issue":"4","key":"e_1_2_12_11_1","first-page":"2443","article-title":"5\u2010aminolevulinic acid\u2010mediated photodynamic therapy effectively ameliorates HPV\u2010infected cervical intraepithelial neoplasia","volume":"14","author":"Chen Y","year":"2022","journal-title":"Am J Transl Res"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2024.2334474"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/03630242.2023.2221742"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010023\u201008634\u2010w"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2021.102293"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/lgt.0000000000000069"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/lgt.0000000000000838"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/lgt.0000000000000708"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u20101743102"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2024.104219"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23727"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8971059"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70273","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:33:36Z","timestamp":1773812016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,5,15]]}},"alternative-id":["10.1002\/ijc.70273"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70273","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"2025-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}