{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:30:29Z","timestamp":1787761829544,"version":"build-2784847793"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R00HD110645"],"award-info":[{"award-number":["R00HD110645"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["Z01\u2010ES044005"],"award-info":[{"award-number":["Z01\u2010ES044005"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ZIAES103399"],"award-info":[{"award-number":["ZIAES103399"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Younger age at menarche is an established uterine cancer risk factor. Age at onset of breast development (thelarche), the earliest marker of pubertal \u201cunopposed\u201d estrogen exposure, may also be relevant to uterine cancer risk, particularly considering rapid declines in age at thelarche over time in parallel with increasing uterine cancer incidence rates. Using data from 34,152 participants with an intact uterus when they enrolled in the US Sister Study cohort (2003\u20132009; ages 35\u201374\u2009years), we examined associations of self\u2010reported ages at thelarche and menarche with incident uterine cancer using multivariable\u2010adjusted Cox proportional hazards regression. We stratified by birth cohort, race, weight relative to peers in childhood, and body mass index (BMI) at enrollment to explore potential effect measure modification and tested for statistical heterogeneity across strata. During follow\u2010up (median\u2009=\u200913.3\u2009years), 445 women reported an incident uterine cancer diagnosis. Ages at thelarche (hazard ratio [HR] per 1\u2010year older: 0.91, 95% confidence interval [CI]: 0.85\u20130.97) and menarche (HR per 1\u2010year older: 0.90, 95% CI: 0.84\u20130.96) were inversely associated with uterine cancer incidence. Associations were similar in non\u2010Hispanic Black and White women and did not vary by relative childhood weight or BMI in adulthood. Inverse associations of thelarche and menarche were limited to women born in 1950 or later (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010het\u2009&lt;.05). These findings suggest that younger ages at thelarche and menarche, markers of earlier and potentially prolonged exposure to estrogen in the absence of progesterone during puberty, may enhance susceptibility to uterine carcinogenesis.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70310","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:26:17Z","timestamp":1766575577000},"page":"2841-2852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pubertal timing and incident uterine cancer in the Sister Study cohort"],"prefix":"10.1002","volume":"158","author":[{"given":"Ariayana N.","family":"Harrell","sequence":"first","affiliation":[{"name":"Department of Sociology The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Epidemiology Branch National Institute of Environmental Health Sciences  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie M.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Epidemiology Branch National Institute of Environmental Health Sciences  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie D.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Clinical Research Branch National Institute of Environmental Health Sciences  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale P.","family":"Sandler","sequence":"additional","affiliation":[{"name":"Epidemiology Branch National Institute of Environmental Health Sciences  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6794-1206","authenticated-orcid":false,"given":"Mandy","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Epidemiology Branch National Institute of Environmental Health Sciences  Research Triangle Park North Carolina USA"},{"name":"Department of Biostatistics and Epidemiology Rutgers School of Public Health  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"National Cancer Institute.Cancer stat facts: uterine cancer.https:\/\/seer.cancer.gov\/statfacts\/html\/corp.html. 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