{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:01:39Z","timestamp":1789182099968,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7242113"],"award-info":[{"award-number":["7242113"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473285"],"award-info":[{"award-number":["82473285"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Although phase II trials have shown that adding docetaxel to S\u20101\/oxaliplatin (DOS) improves pathological response in HER2\u2010negative locally advanced gastric cancer (LAGC), robust real\u2010world evidence comparing DOS with the standard S\u20101\/oxaliplatin (SOX) regimen is lacking. We retrospectively reviewed 1283 consecutive patients with cT2N\n                    <jats:sup>+<\/jats:sup>\n                    or cT3\u20104NanyM0, HER2\u2010negative gastric adenocarcinoma treated with \u22652\u2009cycles of DOS (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009461) or SOX (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009822) at four high\u2010volume Chinese centers between 2010 and 2024. To address confounding, we applied propensity\u2010score matching (PSM, 1:1) and inverse probability\u2010of\u2010treatment weighting (IPTW). Major pathological response (MPR) was the primary endpoint; secondary endpoints included disease\u2010free survival (DFS), overall survival (OS), and perioperative safety. DOS yielded a higher MPR rate than SOX (25.7% vs. 17.8%; OR 1.59, 95% CI 1.14\u20132.23; E\u2010value =1.83 in PSM cohort) without increasing severe postoperative complications (2.2% each). In multivariable Cox models, DOS reduced progression risk (HR 0.74, 95% CI 0.59\u20130.93 in IPTW cohort), while OS was similar after a median 34.8\u2010month follow\u2010up. The DFS advantage was consistent across prespecified subgroups, particularly in patients aged \u226565\u2009years, those with cT2\u20133 or cN0\u20131 disease, and proximal tumors. These findings indicate that neoadjuvant DOS induces deeper pathological regression and longer DFS than SOX without compromising surgical safety, supporting taxane\u2010based triplets as a preferred perioperative option for HER2\u2010negative LAGC; longer follow\u2010up will clarify any impact on OS.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70315","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:57:14Z","timestamp":1766735834000},"page":"2709-2720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neoadjuvant chemotherapy with docetaxel, oxaliplatin, and S\u20101 versus oxaliplatin and S\u20101 for locally advanced gastric adenocarcinoma: A multicenter, real\u2010world cohort study"],"prefix":"10.1002","volume":"158","author":[{"given":"Peng","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Tianjin Medical University Cancer Institute &amp; Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer; Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Gastric Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastric Surgery Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital &amp; Institute  Shenyang Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0390-9466","authenticated-orcid":false,"given":"Zhi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of General Surgery Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haikuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Gastric Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Gastric Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Gastric Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangyao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Gastric Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Gastric Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Gastric Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Gastric Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Gastric Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7189-3999","authenticated-orcid":false,"given":"Yantao","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Gastric Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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