{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:31:34Z","timestamp":1787761894419,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The impact of prior immune checkpoint inhibitor (ICI) therapy on subsequent antiangiogenic treatment efficacy in advanced gastric cancer remains unclear. We retrospectively analyzed 134 patients with advanced gastric cancer who received apatinib as third\u2010line treatment between January 2018 and October 2023, comparing outcomes between those with (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200966) and without (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200968) prior ICI exposure. The ICI\u2010pretreated group demonstrated significantly improved survival outcomes, with longer median progression\u2010free survival (7.1 vs. 4.2\u2009months; HR\u2009=\u20090.42, 95% CI: 0.24\u20130.75,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.003) and overall survival (9.0 vs. 5.1\u2009months; HR\u2009=\u20090.53, 95% CI: 0.31\u20130.91,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.023) compared to the ICI\u2010naive group. Disease control rate was also higher in ICI\u2010pretreated patients (72.7% vs. 61.8%). Subgroup analyses revealed particularly pronounced survival benefits among male patients (HR\u2009=\u20090.30, 95% CI: 0.14\u20130.65), HER2\u2010negative patients (HR\u2009=\u20090.35, 95% CI: 0.18\u20130.69), and those with liver metastases (HR\u2009=\u20090.33, 95% CI: 0.15\u20130.76,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.009). Prior ICI therapy emerged as an independent favorable prognostic factor for survival in multivariate analysis. These findings suggest that prior ICI therapy may enhance the efficacy of subsequent third\u2010line apatinib treatment in patients with advanced gastric cancer, providing important insights for optimizing treatment sequencing strategies in this setting.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70322","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:20:32Z","timestamp":1767014432000},"page":"2912-2919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prior immunotherapy enhances survival outcomes of third\u2010line apatinib treatment in advanced gastric cancer: A retrospective cohort study"],"prefix":"10.1002","volume":"158","author":[{"given":"Chongya","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Wuyi First People's Hospital  Jinhua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8910-9664","authenticated-orcid":false,"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101404"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/10732748221099227"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.934249"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/17588359221110176"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188615"},{"issue":"8","key":"e_1_2_10_7_1","first-page":"887","article-title":"Apatinib for the treatment of gastric cancer","volume":"10","author":"Roviello G","year":"2016","journal-title":"Expert Rev Gastroenterol 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