{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:16:19Z","timestamp":1777634179065,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["ZIA CP010126 \u2010 29"],"award-info":[{"award-number":["ZIA CP010126 \u2010 29"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prenatal exposure to diethylstilbestrol (DES), a prototypical endocrine disruptor, has been associated with increased breast cancer risk after age 40. We assessed the association between prenatal DES exposure and self\u2010reported benign breast disease (BBD)\u2014an established breast cancer risk factor\u2014among 4208 DES\u2010exposed and 1830 unexposed women in the National Cancer Institute DES Follow\u2010up Study. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. Follow\u2010up started at birth and ended at the earliest of: BBD, breast cancer diagnosis, death, or loss to follow\u2010up. We estimated cumulative incidence of BBD by DES exposure. Over the course of the study, 6038 women contributed 333,458 person\u2010years with median follow\u2010up of 43.0 (range: 13.8\u201374.0) years for 1089 BBD cases and 60.0 (range: 19.7\u201380.3) years for 4949 non\u2010cases. Comparing BBD rates among DES\u2010exposed with unexposed women, the HR was 0.97 (95% CI: 0.84, 1.11), with no evidence of a dose\u2013response relationship or difference in cumulative incidence by exposure. In conclusion, the HR for BBD was not elevated among women who were prenatally exposed to DES, suggesting that observed increases in breast cancer risk associated with DES are not due to this pathological mechanism.<\/jats:p>","DOI":"10.1002\/ijc.70331","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T14:22:19Z","timestamp":1769523739000},"page":"3101-3111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal diethylstilbestrol exposure and risk of benign breast disease: The National Cancer Institute Diethylstilbestrol Follow\u2010up Study"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3138-2330","authenticated-orcid":false,"given":"Paloma R.","family":"Mitra","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4565-7618","authenticated-orcid":false,"given":"Kimberly A.","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Slone Epidemiology Center Boston University  Boston Massachusetts USA"},{"name":"Department of Medicine Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7791-2698","authenticated-orcid":false,"given":"Ruth M.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie R.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Slone Epidemiology Center Boston University  Boston Massachusetts USA"},{"name":"Department of Medicine Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumya","family":"Ramireddy","sequence":"additional","affiliation":[{"name":"Department of Medicine Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Hyer","sequence":"additional","affiliation":[{"name":"Information Management Services, Inc.  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