{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:15:59Z","timestamp":1777634159838,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Low triiodothyronine (T3) syndrome, also known as non\u2010thyroidal illness syndrome (NTIS), was one of the common endocrinopathies in critical illness. The potential impacts of low T3 syndrome on survival, endocrine function, and nutritional status of patients with aggressive mature B\u2010cell non\u2010Hodgkin lymphoma (NHL) needed to be explored. We enrolled 225 patients. T3 levels were captured when starting chemotherapy, finishing chemotherapy, and at the first follow\u2010up visit from 6\u2009months after chemotherapy. Latest ultrasound results were recorded. Kaplan\u2013Meier curves were used to compare overall survival (OS) or progression\u2010free survival (PFS). We performed Cox's proportional hazards regression model to analyze prognostic factors of OS and PFS. Ultrasound abnormality and weight gain were tested with the \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    test. The percentage of patients with low T3 syndrome decreased from 55.1% (124 out of 225) to 2.0% (4 out of 201), then further dropped down to 0 (0 out of 173). With a median follow\u2010up of 32.9\u2009months, low T3 syndrome was identified as a statistically significant factor affecting both OS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.047; hazard ratio [HR]\u2009=\u20098.18, 95% CI: 1.03\u201364.97) and PFS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.049; HR\u2009=\u20094.64, 95% CI: 1.01\u201321.31) in multivariate analysis. No significant effects of low T3 syndrome on abnormal thyroid ultrasound results and weight gain were found. In conclusion, low T3 syndrome has a high incidence in pediatric patients with aggressive mature B\u2010cell NHL, and low T3 syndrome has a significant impact on long\u2010term survival. It appears transient and could not contribute to impaired thyroid function.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70335","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T13:34:09Z","timestamp":1768656849000},"page":"3112-3120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low\n                    <scp>T3<\/scp>\n                    syndrome in children with aggressive mature B\u2010cell non\u2010Hodgkin lymphoma"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8236-0985","authenticated-orcid":false,"given":"Da","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, Beijing Children's Hospital, National Center for Children's Health Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children's Hospital, National Center for Children's Health, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Huang","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children's Hospital, National Center for Children's Health, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children's Hospital, National Center for Children's Health, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Jin","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children's Hospital, National Center for Children's Health, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children's Hospital, National Center for Children's Health, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanyu","family":"Dang","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children's Hospital, National Center for Children's Health, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Beijing Children's Hospital, National Center for Children's Health Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Beijing Children's Hospital, National Center for Children's Health Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Beijing Children's Hospital, National Center for Children's Health Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2048-6397","authenticated-orcid":false,"given":"Yanlong","family":"Duan","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Pediatric Oncology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; 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