{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:24:22Z","timestamp":1790688262069,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2307602"],"award-info":[{"award-number":["2023YFC2307602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["823B2086"],"award-info":[{"award-number":["823B2086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273640"],"award-info":[{"award-number":["82273640"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L244091"],"award-info":[{"award-number":["L244091"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720250004"],"award-info":[{"award-number":["20720250004"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    As cervical cancer screening shifts from cytology to HPV testing, clarifying the type\u2010 and age\u2010specific natural history of HR\u2010HPV is crucial, especially in regions with bimodal prevalence patterns where longitudinal data remain limited. We analyzed baseline HR\u2010HPV\u2010positive participants from the control arm of a bivalent HPV\u201016\/18 vaccine trial in China, with follow\u2010up over 5.5\u2009years. Cox regression and competing risk models were applied to evaluate the progression, clearance, and persistence of these HR\u2010HPV infections. Among 534 HR\u2010HPV\u2010positive women at baseline, 98 CIN2+ lesions were identified (52 at baseline, 46 during follow\u2010up). HPV\u201016 and HPV\u201031 exhibited the highest immediate CIN2+ risk (21.1%), followed by HPV\u201033 (17.1%) and HPV\u201058 (12.7%). When stratified by baseline cytology, the LSIL+ group showed the highest immediate risk of CIN2+ (29.5% among the HR\u2010HPV\u2010positive participants), followed by the ASC\u2010US (10.5%). In the longitudinal analysis, competing risk models revealed significant type\u2010specific differences in progression (Gray's test\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0158) and clearance (Gray's test\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;0.0001). HPV\u201016, \u201031, \u201018, and \u201058 showed relatively high progression (27.1%, 19.2%, 16.1%, and 11.2%) and low clearance (72.9%, 69.2%, 83.9%, and 88.8%). CIN2+ risk was strongly genotype\u2010dependent; beyond HPV\u201016\/18, types \u201031, \u201033, and \u201058 also warrant particular attention in screening and clinical management. Additionally, although a slightly higher CIN2+ progression risk was observed in younger women compared to older women, the difference was not statistically significant (Gray's test\n                    <jats:italic>P\u2009=<\/jats:italic>\n                    \u20090.4389), indicating the need for confirmation in larger studies. These findings enhance the understanding of the natural history of type\u2010specific HR\u2010HPV and age\u2010specific progression in initially screen\u2010positive populations.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70337","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:29:13Z","timestamp":1768588153000},"page":"2736-2746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Type\u2010 and age\u2010specific natural history of high\u2010risk human papillomavirus infections in healthy women: A prospective cohort study in China"],"prefix":"10.1002","volume":"158","author":[{"given":"Jiali","family":"Quan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health Xiamen University  Xiamen China"},{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health Xiamen University  Xiamen China"},{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linchen","family":"Lan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health Xiamen University  Xiamen China"},{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health Xiamen University  Xiamen China"},{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyun","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health Xiamen University  Xiamen China"},{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health Xiamen University  Xiamen China"},{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihe","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health Xiamen University  Xiamen China"},{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xibo","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health Xiamen University  Xiamen China"},{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrui","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health Xiamen University  Xiamen China"},{"name":"National Institute of Diagnostics and Vaccine Development in Infectious Diseases, National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, NMPA Key Laboratory for Research and Evaluation of Infectious Disease Diagnostic Technology Xiamen University  Xiamen 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