{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:32:01Z","timestamp":1787761921614,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to evaluate the efficacy and safety of apatinib, an oral VEGFR2 tyrosine kinase inhibitor, combined with docetaxel and S\u20101 (DS) as first\u2010line therapy for metastatic gastric cancer (mGC) patients whose median overall survival (mOS) with chemotherapy typically remains below 12\u2009months. In this prospective, multi\u2010center, single\u2010arm phase II trial (NCT03154983), patients received docetaxel (75\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , day 1) and S\u20101 (body surface area\u2010based dosing, days 1\u201314) every 3\u2009weeks, plus daily apatinib (500\u2009mg), for up to 6 planned cycles. 45 patients were enrolled, with a median follow\u2010up time of 12.4\u2009months. Median progression\u2010free survival (PFS) and overall survival (OS) were 7.6\u2009months (95% CI: 5.8%\u20139.4%) and 12.4\u2009months (95% CI: 9.3%\u201315.5%), respectively in the full analysis set. Patients completing \u22654\u2009cycles achieved a better mOS of 14.5\u2009months (95% CI: 12.0%\u201317.1%). The objective response rate (ORR) and disease control rate (DCR) were 62.2% (95% CI, 46.5%\u201376.2%) and 82.2% (95% CI, 67.9%\u201392.0%), respectively, including one complete response (CR). Grade 3\u20134 treatment\u2010related adverse events occurred in 48.9% of patients, most commonly oral mucositis and neutropenia. These findings support apatinib plus DS as a promising biomarker\u2010independent first\u2010line treatment strategy for mGC.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70351","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T07:34:40Z","timestamp":1770622480000},"page":"2972-2982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Apatinib in combination with docetaxel and S\u20101 chemotherapy as first\u2010line treatment for metastatic gastric cancer"],"prefix":"10.1002","volume":"158","author":[{"given":"Ling","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Radiation and Medical Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4348-1417","authenticated-orcid":false,"given":"Yu","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital Wuhan University  Wuhan China"},{"name":"Hubei Key Laboratory of Tumor Biological Behavior  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huangang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Gong","sequence":"additional","affiliation":[{"name":"Huangshi Central Hospital of Hubei Province  Huangshi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8189-2917","authenticated-orcid":false,"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Abdominal and Pelvic Medical Oncology, The First People's Hospital of Tianmen City Affiliated Hospital of Hubei Technology College  Tianmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hubei Cancer Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5889-9184","authenticated-orcid":false,"given":"Wei","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Oncology, Xiang Yang Central Hospital Hubei University of Art and Science  Xiangyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongjie","family":"Yu","sequence":"additional","affiliation":[{"name":"Cancer Center, Department of Oncology, Shiyan Renmin Hospital  Shiyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9216-5395","authenticated-orcid":false,"given":"Fuxiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital Wuhan University  Wuhan China"},{"name":"Hubei Key Laboratory of Tumor Biological Behavior  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2024.01.006"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61121-X"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-013-0252-z"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i11.1501"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004064.pub4"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.9378"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.4706"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.8429"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073149"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn717"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-013-1563-5"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61719-5"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.5995"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.29.15_suppl.4019"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70420-6"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30791-5"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.2236"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-014-0351-5"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.48.8585"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.e16019"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S196372"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.642511"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.16240"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pst.1654"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn166"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.05.021"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e328345b509"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0124-3"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.17.376"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn403"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.09.025"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-020-01112-1"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00515-6"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00797-2"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-078876"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.11.039"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds145"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0521-0"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-4691"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319748"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.5805"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.6136"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.9824"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02033-0"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.3707"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.28463"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aak9679"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-17-0640"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:07:39Z","timestamp":1787760459000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,8]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1002\/ijc.70351"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70351","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,8]]},"assertion":[{"value":"2025-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}