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We aim to explore the effect of tobacco cessation on the risk of buccal mucosa cancer (BMC). A case\u2013control study was conducted across five cancer centres in India. We enrolled 2320 BMC and 2302 frequency\u2010matched controls. Information was collected on smoking and chewing (products, duration and quitting). Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) of the effect of tobacco cessation compared to current users, after adjusting for potential confounders. For both smoking and chewing, the odds reduced rapidly after 5\u2009years of quitting, so that those who had quit smoking \u226510\u2009years ago had only 0.39 (95% CI 0.28\u20130.54) the odds of BMC compared to those who continued to smoke, and those who quit chewing \u226510\u2009years ago had 0.58 (95% CI 0.43\u20130.81) the odds of BMC compared to those who continued to chew. Chewing with areca nut was associated with almost double the risk of chewing without (OR 1.86, 95% CI 1.53\u20132.26) but the rate of reduction of risk with quitting was similar. These findings show clearly the benefits of quitting and inform policies that emphasize chewing tobacco cessation, given its widespread prevalence in India.<\/jats:p>","DOI":"10.1002\/ijc.70372","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T08:41:14Z","timestamp":1770626474000},"page":"368-377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of tobacco cessation on buccal mucosa cancer risk: A multi\u2010centre case\u2013control study in India"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4601-1465","authenticated-orcid":false,"given":"Gayathri B.","family":"Pullat","sequence":"first","affiliation":[{"name":"Division of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology Tata Memorial Centre  Navi Mumbai India"},{"name":"Department of Health Sciences Homi Bhabha National Institute (HBNI)  Mumbai 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