{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:46:39Z","timestamp":1788536799858,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020812","name":"Robert K Steel Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Relapse of high\u2010risk neuroblastoma (HR\u2010NB) poses a challenge to cure. Increasing numbers of HR\u2010NB patients achieve post\u2010relapse complete remission (CR) because close monitoring can detect localized disease and novel effective salvage therapies have emerged. We report outcome with immunotherapy using the anti\u2010G\n                    <jats:sub>D2<\/jats:sub>\n                    monoclonal antibody (mAb) naxitamab and granulocyte\u2010macrophage colony\u2010stimulating factor (GM\u2010CSF) for consolidation of second or later CR in a phase II trial (Clinicaltrials.gov NCT01757626). Cycles included GM\u2010CSF 250\u2009\u03bcg\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/day on days \u22124\u2010to\u20100 and increased to 500\u2009\u03bcg\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/day on days +1\u2010to\u20105, and 3 doses of naxitamab infused (30\u2010to\u201090\u2009min) on days +1\/+3\/+5, 3\u2009mg\/kg\/infusion (9\u2009mg\/kg\/cycle, i.e., ~270\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    \/cycle). Cycles were monthly \u00d75. Clinical factors assessed regarding prognosis were:\n                    <jats:italic>MYCN<\/jats:italic>\n                    amplification; localized versus widespread prior relapse; 1 versus \u22652 prior relapse(s); previous treatment with anti\u2010G\n                    <jats:sub>D2<\/jats:sub>\n                    mAb; and time from diagnosis to 1st relapse. Sixty patients were enrolled after 1 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200942) or \u22652 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200918) prior relapse(s); 27 (45%) had\n                    <jats:italic>MYCN<\/jats:italic>\n                    amplification. Progression\u2010free survival (PFS) rates at 2\/5\u2009years were 55%\/50%. Prior treatment with naxitamab and prior widespread relapse had significant negative impacts on PFS. Post\u2010protocol patients in CR routinely received an investigational anti\u2010NB vaccine. Two other patients, both with 1 prior relapse, took DFMO. Naxitamb+GM\u2010CSF is a good option to consolidate post\u2010relapse CR of HR\u2010NB. The encouraging long\u2010term outcome cannot be attributed solely to naxitamab+GM\u2010CSF given post\u2010protocol therapies.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70374","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:11:42Z","timestamp":1770819102000},"page":"3232-3240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A phase\n                    <scp>II<\/scp>\n                    trial of naxitamab plus stepped\u2010up dosing of\n                    <scp>GM<\/scp>\n                    \u2010\n                    <scp>CSF<\/scp>\n                    for patients with high\u2010risk neuroblastoma in second or later complete remission"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-0697","authenticated-orcid":false,"given":"Brian H.","family":"Kushner","sequence":"first","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-1726","authenticated-orcid":false,"given":"Shakeel","family":"Modak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie","family":"White","sequence":"additional","affiliation":[{"name":"Department of Biostatics and Epidemiology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen S.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Department of Pediatrics Oregon Health &amp; Science University, Knight Cancer Institute  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Mauguen","sequence":"additional","affiliation":[{"name":"Department of Biostatics and Epidemiology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai\u2010Kong V.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23507"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.06.010"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22693"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.3392"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318299d637"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.302"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26192"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30934"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26940"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2562"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00703"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00203"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010023\u201002457\u2010x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002297\u20105"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00458"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.6107"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1016704"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29121"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01630"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12196196"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0911123"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201020\u20103909"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(18)30578\u20103"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12020309"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28851"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.3807"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.19864"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4005"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.7.1936.1936"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056,619\u2010x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1627"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.7272"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.72.0177"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(13)70309\u20107"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.02.101"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(08)70069\u2010X"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010022\u201001383\u20104"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01892"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33044"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201024\u20103427"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28137"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.14.3397"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.10555"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.10.020"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.09.005"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02478"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2015.1130196"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10100387"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6393"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20513"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003455"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409\u2010021\u201001258\u20101"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae062"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70374","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:05:22Z","timestamp":1777439122000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,6,15]]}},"alternative-id":["10.1002\/ijc.70374"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70374","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]},"assertion":[{"value":"2025-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}