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We developed five evidence and gap maps using 188 studies identified in the International Agency for Research on Cancer\n                    <jats:italic>Handbooks of Cancer Prevention<\/jats:italic>\n                    Volume 19 on Oral Cancer Prevention, across five categories of interventions: (1) exposure to preventive dietary agents, (2) quitting exposure to oral cancer risk factors, (3) interventions for smokeless tobacco (SLT) and areca nut cessation, (4) SLT and areca nut control policies, and (5) secondary prevention. The largest number of studies addressed the effect of quitting exposure to a risk factor (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200957) and control policy interventions (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200951); 34 studies focused on interventions for SLT and areca nut cessation, 32 evaluated preventive dietary agents, and only 15 assessed secondary prevention. Numerous research gaps were identified, including few youth\u2010targeted studies, a paucity of informative studies evaluating risk reversal upon cessation of use of SLT or areca nut with or without tobacco, negligible evidence on interventions for cessation of use of areca nut with or without tobacco, minimal literature on areca nut control policies, and few studies on screening of high\u2010risk individuals. Overall, the findings highlight the need for further research on multiple areas of SLT and areca nut control in high\u2010burden regions. The findings can inform public health decision\u2010making and support more targeted, evidence\u2010based public health strategies to reduce the burden of oral cancer globally.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70391","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:09:48Z","timestamp":1772957388000},"page":"188-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interventions for oral cancer prevention: An evidence and gap map"],"prefix":"10.1002","volume":"159","author":[{"given":"Suzanne Tanya","family":"Nethan","sequence":"first","affiliation":[{"name":"IARC Handbooks Programme, Evidence Synthesis and Classification Branch International Agency for Research on Cancer (IARC\/WHO)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eduarda","family":"P\u00e9rez\u2010de\u2010Oliveira","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Campbell","sequence":"additional","affiliation":[{"name":"Centre for Evidence and Implementation Science, University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-6617","authenticated-orcid":false,"given":"Alan Roger","family":"Santos\u2010Silva","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Lauby\u2010Secretan","sequence":"additional","affiliation":[{"name":"IARC Handbooks Programme, Evidence Synthesis and Classification Branch International Agency for Research on Cancer (IARC\/WHO)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"FerlayJ ErvikM LamF et al.Global cancer observatory: cancer today.2024. 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