{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:34:03Z","timestamp":1787762043056,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Soft\u2010tissue sarcomas (STS) comprise over 150 histological subtypes, with advanced cases showing poor prognosis (5\u2010year survival &lt;10%). Trabectedin, a synthetic alkaloid, is frequently used after anthracycline\u2010based chemotherapy failure. Despite the withdrawal of reimbursement in France in 2016 due to debated efficacy and safety, it remains in clinical use, imposing financial strain on hospitals. This retrospective single\u2010center study evaluated trabectedin's efficacy, safety, and cost in 68 patients treated between 2019 and 2023. L\u2010sarcomas accounted for 78% of cases, including uterine leiomyosarcomas (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916), soft\u2010tissue leiomyosarcomas (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200917), and myxoid liposarcomas (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098). Non\u2010L\u2010sarcomas (22%) included mostly synovial sarcomas. The overall disease control rate was 71%, with a median progression\u2010free survival (PFS) of 4.1\u2009months, and an overall survival of 12.3\u2009months. Subtype\u2010specific median PFS was 6.8\u2009months for liposarcomas (11.3 for myxoid vs. 4.5 for other subtypes), 3.1\u2009months for leiomyosarcomas (3.4\u2009months for uterine vs. 3.1 for soft\u2010tissue), and 2.4\u2009months for non\u2010L\u2010sarcomas. Patients received a median of 5\u2009cycles (range: 1\u201338), with an average total dose of 16\u2009mg [2\u201381], and an average hospital cost of \u20ac9900. Adverse events occurred in 91%, mainly hematological; cardiac toxicity was seen in 9%. This retrospective single\u2010center study in a limited cohort provides real\u2010world insights but should be interpreted with caution. Despite limited reimbursement, trabectedin may retain clinical utility, particularly in L\u2010sarcoma management.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70403","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:25:09Z","timestamp":1773005109000},"page":"234-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trabectedin in the treatment of soft tissue sarcoma: Real\u2010world data on effectiveness, safety, and financial implications from a European comprehensive cancer center"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9160-0842","authenticated-orcid":false,"given":"Jean\u2010St\u00e9phane","family":"Giraud","sequence":"first","affiliation":[{"name":"D\u00e9partement de Pharmacie Institut Curie, PSL Research University  Paris France"},{"name":"Institut Cochin, Inserm U1016, CNRS UMR8104 Universit\u00e9 Paris Cit\u00e9, CARPEM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4534-8783","authenticated-orcid":false,"given":"Sarah","family":"Watson","sequence":"additional","affiliation":[{"name":"Department d'Oncologie M\u00e9dicale Institut Curie, PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Acramel","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacie Institut Curie, PSL Research University  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, CiTCoM, CNRS UMR 8038, Inserm U1268  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Laurence","sequence":"additional","affiliation":[{"name":"Department d'Oncologie M\u00e9dicale Institut Curie, PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Tzanis","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Institut Curie, PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Bonvalot","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Institut Curie, PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"El Zein","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Diagnostique et Th\u00e9ranostique Institut Curie, PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayla","family":"Nicolas","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Imagerie M\u00e9dicale Institut Curie, PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Cros","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacie Institut Curie, PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Desmaris","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacie Institut Curie, PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Department d'Oncologie M\u00e9dicale Institut Curie, PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010024\u201002674\u2010y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2021.102312"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.32074\/1591\u2010951X\u2010213"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.72800"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000527602"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123784"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864\u2010019\u20100606\u20109"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.07.006"},{"key":"e_1_2_11_10_1","unstructured":"European Medicines Agency (EMA).Yondelis; 2009. 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