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Long non\u2010coding RNAs, such as\n                    <jats:italic>PVT1<\/jats:italic>\n                    , play key roles in cancer, particularly by regulating gene expression.\n                    <jats:italic>PVT1<\/jats:italic>\n                    is upregulated in several cancer types and has been shown to interact with the androgen receptor in prostate cells. This study investigates how\n                    <jats:italic>PVT1<\/jats:italic>\n                    contributes to the prostate cancer phenotype under androgen stimulation. Knockdown of\n                    <jats:italic>PVT1<\/jats:italic>\n                    was achieved using CRISPR\u2010Cas13d in LNCaP prostate cancer cells subjected to androgen (R1881) or vehicle treatment. Cellular proliferation, invasion, and apoptosis rates were assessed, alongside RNA sequencing (RNA\u2010seq) to analyze genome\u2010wide transcriptomic changes. Six epigenetic marks\u2014AR, EZH2, H3K4me1, H3K4me3, H3K27me3, and H3K27ac\u2014were examined using CUT&amp;RUN.\n                    <jats:italic>PVT1<\/jats:italic>\n                    knockdown led to a significant reduction in cell proliferation and an increase in apoptosis signaling. Oncogenes such as\n                    <jats:italic>MYC<\/jats:italic>\n                    ,\n                    <jats:italic>AKT1<\/jats:italic>\n                    ,\n                    <jats:italic>AKT2<\/jats:italic>\n                    , cyclins\n                    <jats:italic>CCNA2<\/jats:italic>\n                    ,\n                    <jats:italic>CCNB1<\/jats:italic>\n                    ,\n                    <jats:italic>CCNB2<\/jats:italic>\n                    ,\n                    <jats:italic>CCNE1<\/jats:italic>\n                    ,\n                    <jats:italic>CCNE2<\/jats:italic>\n                    and cyclin\u2010dependent kinases\n                    <jats:italic>CDK1<\/jats:italic>\n                    and\n                    <jats:italic>CDK4<\/jats:italic>\n                    , which were upregulated under androgen treatment, exhibited a significantly reduced expression following\n                    <jats:italic>PVT1<\/jats:italic>\n                    knockdown, thereby modulating cancer\u2010associated oncogenic pathways. Epigenetically,\n                    <jats:italic>PVT1<\/jats:italic>\n                    knockdown markedly decreased the occupancy of transcriptionally activating epigenetic marks\u2014H3K4me1, H3K4me3, and H3K27ac\u2014on oncogenes, regardless of androgen presence. Analysis of enriched transcription factors associated with the altered genes revealed a regulatory network linked to prostate cancer pathogenesis.\n                    <jats:italic>PVT1<\/jats:italic>\n                    drives a genome\u2010wide epigenetic reprogramming in prostate cells, underscoring the role of\n                    <jats:italic>PVT1<\/jats:italic>\n                    as a positive regulator of oncogenic pathways in prostate cancer and highlighting\n                    <jats:italic>PVT1<\/jats:italic>\n                    's potential as a therapeutic target.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70417","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:51:21Z","timestamp":1772988681000},"page":"144-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>\n                      <i>PVT1<\/i>\n                      lincRNA\n                    <\/scp>\n                    signals an androgen\u2010dependent transcriptional activation program of oncogenes in prostate cancer cells"],"prefix":"10.1002","volume":"159","author":[{"given":"Maria Gabriela","family":"Berzoti\u2010Coelho","sequence":"first","affiliation":[{"name":"Cell Cycle Laboratory Instituto Butantan  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Nunes","family":"de Mello","sequence":"additional","affiliation":[{"name":"Cell Cycle Laboratory Instituto Butantan  S\u00e3o Paulo Brazil"},{"name":"Bioinformatics Interunits Graduate Program Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Tahira","sequence":"additional","affiliation":[{"name":"Cell Cycle Laboratory Instituto Butantan  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel 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