{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:27:11Z","timestamp":1786562831871,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100032253","name":"Nordic Cancer Union","doi-asserted-by":"publisher","award":["171734"],"award-info":[{"award-number":["171734"]}],"id":[{"id":"10.13039\/100032253","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Data on cancer risk in offspring of men with testicular germ cell cancer (TC) remain limited. We assessed the risk of childhood and adolescent and young adult (AYA) cancer in offspring of men with TC. Men diagnosed with TC in the Danish Cancer Registry (1943\u20132017) were identified (TC probands). For each TC proband, 10 men matched on birth year, alive, and cancer\u2010free at the proband's date of diagnosis were selected from the National Civil Registration System (non\u2010TC probands). Offspring were identified in the Danish Birth Registry, with cancer diagnoses obtained from national registries. Cumulative incidences, hazard ratios (HRs), with 95% confidence intervals (CIs) were calculated for childhood cancer (0\u201314\u2009years) and AYA cancer (15\u201339\u2009years), including TC specifically versus other cancers. Offspring were included regardless of whether they were born before or after their father's diagnosis (for TC probands) or the corresponding index date (for non\u2010TC probands). Childhood cancer rates were similar between sons of TC probands and non\u2010TC probands (HR 1.0, 95% CI 0.6\u20131.7) and daughters (HR 1.1, 95% CI 0.6\u20131.9). For AYA cancer, rates in daughters were comparable, while sons of TC probands had an increased rate (HR 1.9, 95% CI 1.6\u20132.4). This increase was driven by TC (HR 3.6, 95% CI 2.7\u20134.8), with no significant difference in rates of other cancers. The rate of childhood cancer in offspring of men with TC is comparable to the rate of the general population, while the elevated AYA cancer rate in sons is attributable to a higher rate of TC.<\/jats:p>","DOI":"10.1002\/ijc.70420","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:21:37Z","timestamp":1773008497000},"page":"629-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of childhood and adolescent, and young adult cancer in offspring of men with testicular cancer: A Danish nationwide study"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-9675","authenticated-orcid":false,"given":"Mikkel","family":"Bandak","sequence":"first","affiliation":[{"name":"Department of Oncology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Rosth\u00f8j","sequence":"additional","affiliation":[{"name":"Statistics and Data Analysis Danish Cancer Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte Lerche","family":"Aalborg","sequence":"additional","affiliation":[{"name":"Statistics and Data Analysis Danish Cancer Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-174X","authenticated-orcid":false,"given":"Jakob","family":"Lauritsen","sequence":"additional","affiliation":[{"name":"Department of Oncology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Giwercman","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hege Sagstuen","family":"Haugnes","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, UIT \u2010 The Arctic University  Tromso Norway"},{"name":"Department of Oncology University Hospital of North Norway  Tromso Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gedske","family":"Daugaard","sequence":"additional","affiliation":[{"name":"Department of Oncology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8124-4880","authenticated-orcid":false,"given":"Allan","family":"Jensen","sequence":"additional","affiliation":[{"name":"Virus, Lifestyle and Genes Danish Cancer Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33999"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.08.020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2019.06.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab130"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09606-X"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del292"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del084"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pky027"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.085"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgi020"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805073381902"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgi019"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24856"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002816"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq550"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601714"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.12.031"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19960529)66:5<627::AID-IJC8>3.0.CO;2-V"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0445-2"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91012-9"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1508054"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24334-y"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.01.021"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810393562"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010018\u20100356\u20101"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(96)00075-X"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6025"},{"key":"e_1_2_11_30_1","unstructured":"R Core Team.R: A Language and Environment for Statistical Computing.R Foundation for Statistical Computing;2023.https:\/\/www.r-project.org\/"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13889"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.01.002"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.05.038"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70420","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70420","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:30:16Z","timestamp":1786559416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,8,1]]}},"alternative-id":["10.1002\/ijc.70420"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70420","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]},"assertion":[{"value":"2025-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}