{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:27:18Z","timestamp":1786562838598,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["FOSISS 2013 202468"],"award-info":[{"award-number":["FOSISS 2013 202468"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Extended high\u2010risk human papilloma virus (hrHPV) typing emerges as a potential alternative for detecting cervical intraepithelial neoplasia 3 (CIN3), without additional triage tests. We evaluate the extended hrHPV typing as an alternative to improve CIN3 detection within an HPV\u2010based screening program. Between January 2017 and August 2018, 5856 women aged 25\u201365\u2009years were screened as part of a public cervical cancer screening program of the Tlalpan Sanitary Jurisdiction in Mexico City. HPV testing was performed by BD Onclarity\u2122, which individually detects hrHPV types 16, 18, 31, 45, 51, and 52, and pools of types 33\/58, 56\/59\/66, and 35\/39\/68. Specific hrHPV types within these pools were further identified using the Atila AmpFire platform. All HPV\u2010positive women (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009691) were referred to colposcopy evaluation for diagnostic confirmation. Of these, 561 women completed both colposcopy and histological confirmation, representing our analytical sample. HPV\u201016 alone had a sensitivity of 43.0% and specificity of 85.4% for CIN3 detection. Sequentially adding HPV\u201018\/33\/31\/39 increased sensitivity to 100% for CIN3 detection, although with lower specificity (54.5%). The proportion of HPV\u201016\/18\/33\/31\/39 positive women was 47.0%, with a CIN3 PPV 5.3%. Extended genotyping with HPV\u201016\/18\/33\/31\/39 achieved 100% sensitivity for CIN3 detection, but a moderate specificity. This strategy aligns with the international recommendation for colposcopy referral in women with a PPV of CIN3 larger than 4.0%.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70428","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T13:34:58Z","timestamp":1774704898000},"page":"638-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extended\n                    <scp>HPV<\/scp>\n                    typing as an efficient alternative within\n                    <scp>HPV<\/scp>\n                    \u2010based screening programs"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4217-1521","authenticated-orcid":false,"given":"Joacim","family":"Meneses\u2010Le\u00f3n","sequence":"first","affiliation":[{"name":"Research Center in Policy, Population, and Health, School of Medicine National Autonomous University of Mexico  Mexico City 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Subgerencia T\u00e9cnica del Plan de Salud, Gerencia de Administraci\u00f3n del Plan de Salud, Banco de M\u00e9xico  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8701-6424","authenticated-orcid":false,"given":"Jos\u00e9 Dami\u00e1n","family":"Cadena\u2010Fiscal","sequence":"additional","affiliation":[{"name":"Department of Systems, Statistics, Informatics and Information Analysis Sanitary Jurisdiction  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6317-5233","authenticated-orcid":false,"given":"Anna B.","family":"Moscicki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics David Geffen School of Medicine at UCLA  Los Angeles California 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