{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:40:29Z","timestamp":1789206029386,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020537","name":"Merck Sharp and Dohme Australia","doi-asserted-by":"publisher","award":["IS100938"],"award-info":[{"award-number":["IS100938"]}],"id":[{"id":"10.13039\/100020537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The incidence of human papillomavirus (HPV)\u2010positive oropharyngeal cancer (OPC) is increasing in Australia, yet very little is known about the dynamics of the HPV types in OPC over time. Here we used a database to identify oropharyngeal cancer patients diagnosed in Queensland in 2009\u20132011 and 2019\u20132021. We retrieved and extracted DNA from 526 formalin\u2010fixed paraffin\u2010embedded tumour tissues, which were tested for DNA quality and 14 high\u2010risk (HR)\u2010HPV types. The HPV prevalence in OPC tumour tissue increased from 45% in 2009\u20132011 to 68% in 2019\u20132021. HPV\u201016 was the most common HPV type, found in 90% of all OPCs. HPV\u201033 (5.7%) was the second most common HPV type followed by HPV\u201035 (1.6%). Other HPV types found were HPV\u201018 (1.4%), HPV\u201039 (0.3%), HPV\u201056 (0.6%) and HPV\u201059 (0.6%). Males had a significantly higher HPV prevalence (68.1%) compared to females (35.9%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001). First Nation Australians had much lower HPV prevalence in their OPC tumours (25.0%) compared with non\u2010First Nation Australians (68.8%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.0005). Without an early detection program for OPC, primary prevention with vaccination remains the best available strategy for control, and our findings suggest that HPV vaccination will be able to reduce HPV\u2010driven OPC in the future.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70432","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:44:05Z","timestamp":1772988245000},"page":"750-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence and distribution of\n                    <scp>HPV<\/scp>\n                    types in Australian patients with oropharyngeal cancer over time"],"prefix":"10.1002","volume":"159","author":[{"given":"Lachlan","family":"Yaksich","sequence":"first","affiliation":[{"name":"Department of Plastics and Reconstructive Surgery Greenslopes Private Hospital  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Hartel","sequence":"additional","affiliation":[{"name":"The Population Health Program QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"Griffith Institute for Biomedicine and Glycomics Griffith University  Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedict J.","family":"Panizza","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Princess Alexandra Hospital  Brisbane Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Whiteman","sequence":"additional","affiliation":[{"name":"The Population Health Program QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Antonsson","sequence":"additional","affiliation":[{"name":"The Population Health Program QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"F55","article-title":"Papillomavirus infections\u2010a major cause of human cancers","volume":"1288","author":"zur Hausen H","year":"1996","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"e_1_2_12_3_1","first-page":"S3\/11","article-title":"Chapter 2: the burden of HPV\u2010related cancers","volume":"24","author":"Parkin 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