{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:27:12Z","timestamp":1786562832172,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The prospective, German NICO study (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: NCT02990611) evaluated real\u2010world effectiveness and safety with nivolumab plus ipilimumab or nivolumab alone (any\u2010line) in patients with advanced melanoma with\/without melanoma brain metastasis (MBM). A total of 755 patients treated with nivolumab plus ipilimumab (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009486; median follow\u2010up, 46.8\u2009months) or nivolumab alone (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009269; median follow\u2010up, 38.7\u2009months) were enrolled. Baseline characteristics differed between the treatment groups, with the nivolumab plus ipilimumab group being younger and having poorer prognostic factors. At baseline, 221 patients (29.3%) had MBM, among whom 15 patients had symptomatic MBM based on dexamethasone use. In patients with\/without MBM receiving first\u2010line nivolumab plus ipilimumab, objective response rates (ORRs) were 46.2% and 54.0%, respectively; 3\u2010year overall survival (OS) rates were 34.0% and 47.0%. In patients with\/without MBM receiving first\u2010line nivolumab alone, ORRs were 61.5% and 55.1%, respectively; 3\u2010year OS rates were 42.7% and 47.8%. In a 3\u2010month landmark analysis, patients with MBM with a complete\/partial response demonstrated 3\u2010year OS rates of 71.9% with nivolumab plus ipilimumab and 89.6% with nivolumab alone. Three\u2010year OS rates were 42.2% and 20.0% with asymptomatic and symptomatic MBM, respectively. There were no substantial differences in the rates of serious grade 3\/4 treatment\u2010related adverse events between patients with\/without MBM. HRQoL was stable. Results from this real\u2010world study show that a substantial proportion of patients with MBM derive long\u2010term benefit from nivolumab plus ipilimumab or nivolumab alone, particularly those with asymptomatic MBM.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70440","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T03:34:56Z","timestamp":1773632096000},"page":"683-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010world effectiveness and safety with nivolumab plus ipilimumab or nivolumab alone in patients with or without melanoma brain metastasis: Results from the German noninterventional\n                    <scp>NICO<\/scp>\n                    study"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7921-2820","authenticated-orcid":false,"given":"Ralf","family":"Gutzmer","sequence":"first","affiliation":[{"name":"Department of Dermatology Johannes\u2013Wesling\u2013Klinikum Minden\/Ruhr\u2013University Bochum  Minden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-4961","authenticated-orcid":false,"given":"Michael","family":"Weichenthal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Schleswig\u2010Holstein University Hospital (UK\u2014SH), Campus Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Eigentler","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mohr","sequence":"additional","affiliation":[{"name":"Department of Dermatology Elbe\u2010Klinikum Buxtehude  Buxtehude Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sickmann","sequence":"additional","affiliation":[{"name":"Medical Department Bristol Myers Squibb  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"D\u00fccker","sequence":"additional","affiliation":[{"name":"Department of Dermatology Klinikum Dortmund  Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7090-9584","authenticated-orcid":false,"given":"Christoffer","family":"Gebhardt","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Medical Center Hamburg\u2010Eppendorf  Hamburg 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