{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T07:48:04Z","timestamp":1782114484397,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01KD2104A"],"award-info":[{"award-number":["01KD2104A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The incidence of obesity and early\u2010onset colorectal cancer (CRC) has rapidly increased in recent decades. We estimated CRC risk differences by body mass index (BMI) and derived corresponding BMI\u2010specific CRC screening initiation ages across multiple countries, to help refine the timing of CRC prevention. We based our analyses on population\u2010level CRC incidence data from the GLOBOCAN database (2022) and risk estimates from a meta\u2010analysis of six cohort studies. The analysis included adults aged 30 to 60\u2009years from six countries: United States, Canada, Germany, France, United Kingdom, and Italy. Individuals with overweight were used as the reference category, reflecting the average BMI of adults eligible for screening in these countries. Risk\u2010adapted screening initiation ages were defined as the ages at which individuals with obesity reached the same 5\u2010year cumulative CRC risk as those with overweight at ages 45 and 50 (aCR\n                    <jats:sub>45<\/jats:sub>\n                    and aCR\n                    <jats:sub>50<\/jats:sub>\n                    ). Compared with individuals with overweight, those with normal weight had a lower risk of early\u2010onset CRC (OR, 0.76; 95% CI, 0.68\u20130.84), while those with obesity had higher risk (OR, 1.42; 95% CI, 1.04\u20131.95). Across countries, individuals with obesity reached the aCR\n                    <jats:sub>45<\/jats:sub>\n                    at age 41 to 42\u2009years and the aCR\n                    <jats:sub>50<\/jats:sub>\n                    at age 46 to 47\u2009years. These findings indicate that individuals with obesity reached CRC screening thresholds up to 3\u20134\u2009years earlier than those at average risk. BMI may offer a practical and scalable marker to inform personalized CRC screening initiation, with the potential to enhance early detection if integrated into existing screening programs.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70448","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:45:35Z","timestamp":1775796335000},"page":"876-882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["At what age should people with obesity start colorectal cancer screening?"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4475-0583","authenticated-orcid":false,"given":"Teresa","family":"Seum","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology of Early Cancer Detection, German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Medical Faculty Heidelberg Heidelberg University  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Mandic","sequence":"additional","affiliation":[{"name":"Cancer Prevention Graduate School, German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Safizadeh","sequence":"additional","affiliation":[{"name":"Cancer Prevention Graduate School, German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8307-3197","authenticated-orcid":false,"given":"Michael","family":"Hoffmeister","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology of Early Cancer Detection, German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-1572","authenticated-orcid":false,"given":"Hermann","family":"Brenner","sequence":"additional","affiliation":[{"name":"Cancer Prevention Graduate School, German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102018\u2010317592"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384\u2010020\u201003558\u20102"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.07.035"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010020\u201000445\u20101"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(21)00426\u2010X"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12061408"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010024\u201005890\u20104"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010024\u201001969\u20103"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155402"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)02750\u20102"},{"key":"e_1_2_11_12_1","unstructured":"ArnoldM LamF ErvikM SoerjomataramI.Cancer and Obesity: Global burden of cancer attributable to excess weight. 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