{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T16:05:33Z","timestamp":1779379533052,"version":"3.53.1"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is critical to improving the overall prognosis. However, biomarkers for early diagnosis are lacking. We used pre\u2010diagnostic plasma samples from 1307 PDAC cases and individually matched cancer\u2010free controls from five prospective cohort studies. Conditional logistic regression was used to assess the association of circulating miRNAs with PDAC risk. Linear regression was conducted to identify miRNAs ratio (miRNA levels of case over their matched control) change associated with the lead time from blood draw to PDAC diagnosis. We found 20 miRNAs significantly associated with PDAC risk (\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>FDR<\/jats:sub>\n                    \u2009&lt;\u2009.05). Among them, 13 miRNAs showed a significant ratio change within 10\u2009years prior to cancer diagnosis. The case\u2013control difference of miR\u2010155\u20105p and miR\u2010493\u20103p increased when blood draw was closer to PDAC diagnosis. While the ratio changes of the remaining 11 miRNAs decreased. Adding 13 miRNAs to known risk factors and CA19\u20109 significantly improved the prediction performance for imminent PDAC risk, with AUCs of 85%, 77%, and 73% during the time windows of 1, 2, and 3\u2009years prior to PDAC diagnosis. Findings of this large prospective study shield a light on the biology of PDAC and suggest a potential utility of monitoring circulating miRNAs for PDAC risk surveillance among high\u2010risk individuals.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70452","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:17:44Z","timestamp":1773807464000},"page":"526-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamics of the association between circulating levels of\n                    <scp>miRNA<\/scp>\n                    and pancreatic cancer risk through the years prior to pancreatic cancer diagnosis"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2388-1694","authenticated-orcid":false,"given":"Hui","family":"Cai","sequence":"first","affiliation":[{"name":"Division of Epidemiology, Department of Medicine Vanderbilt University 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyin","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0711-8314","authenticated-orcid":false,"given":"Xiao\u2010Ou","family":"Shu","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"American Cancer Society.Survival Rates for Pancreatic Cancer.2025https:\/\/www.cancer.org\/cancer\/types\/pancreatic\u2010cancer\/detection\u2010diagnosis\u2010staging\/survival\u2010rates.htmlAccessed June 30 2025."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10100752"},{"key":"e_1_2_12_4_1","unstructured":"American Cancer Society.Key Statistics for Pancreatic Cancer.2025https:\/\/www.cancer.org\/cancer\/types\/pancreatic-cancer\/about\/key-statistics.htmlAccessed June 30 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