{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T07:48:08Z","timestamp":1782114488627,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Colorectal cancer (CRC) is a leading cause of cancer\u2010related deaths worldwide, underscoring the urgent need for precise and personalized therapeutic strategies. Globo\u2010H has emerged as a clinically relevant glycan target with promising diagnostic and therapeutic utility across multiple cancer types. In this study, we stratified colorectal cancer patients into Globo\u2010H\u2010high and Globo\u2010H\u2010low groups using a histology\u2010based classification, followed by RNA\u2010sequencing analyses to elucidate the key signaling pathways associated with Globo\u2010H overactivation. Among the 31 genes that were identified to meet the Globo\u2010H histology criterion, DUSP14 (dual specificity phosphatase 14) emerged as a promising pharmacological target associated with Globo\u2010H abundance. DUSP14 is an underexplored but pharmacologically actionable therapeutic target. DUSP14 protein in colon cancer cells is inversely correlated with total Transforming growth factor\u2010\u03b2\u2010activated kinase 1 (TAK1) protein. The druggability of DUSP14 was demonstrated through in vitro using cell lines and patient\u2010derived organoids (PDO). These results enhance current diagnostic frameworks and provide a foundation for developing novel targeted therapies. Further, in vivo studies are warranted to evaluate the potential of Globo\u2010H targeting in combination with standard treatment regimens. Overall, our work highlights the value of integrating PDO\u2010based functional assays with molecular profiling to uncover and validate actionable targets for CRC theranostics.<\/jats:p>","DOI":"10.1002\/ijc.70461","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:21:26Z","timestamp":1775100086000},"page":"936-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Globo\u2010H diagnostic stratification and identification of\n                    <scp>DUSP14<\/scp>\n                    as a candidate target in colorectal cancer"],"prefix":"10.1002","volume":"159","author":[{"given":"Keren","family":"Zohar","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry, Institute of Life Sciences The Hebrew University of Jerusalem  Jerusalem 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Medicine Otto\u2010von\u2010Guericke\u2010University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederike","family":"Stelter","sequence":"additional","affiliation":[{"name":"Molecular and Experimental Surgery, Department of General, Visceral, Vascular and Transplantation Surgery, Faculty of Medicine Otto\u2010von\u2010Guericke\u2010University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Doelling","sequence":"additional","affiliation":[{"name":"Molecular and Experimental Surgery, Department of General, Visceral, Vascular and Transplantation Surgery, Faculty of Medicine Otto\u2010von\u2010Guericke\u2010University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihailo","family":"Andric","sequence":"additional","affiliation":[{"name":"Molecular and Experimental Surgery, Department of General, Visceral, Vascular and Transplantation Surgery, Faculty of Medicine Otto\u2010von\u2010Guericke\u2010University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Or","family":"Kakhlon","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Anges Ginges Center for Human Neurogenetics Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"T\u00e4ger","sequence":"additional","affiliation":[{"name":"Institute for Experimental Medicine, Faculty of Medicine Otto\u2010von\u2010Guericke\u2010University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denny","family":"Schanze","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Faculty of Medicine Otto\u2010von\u2010Guericke\u2010University Magdeburg  Magdeburg 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