{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T07:48:06Z","timestamp":1782114486090,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472082"],"award-info":[{"award-number":["82472082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302322"],"award-info":[{"award-number":["82302322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Patients with liver metastases generally have poorer outcomes following immunotherapy compared with those without liver involvement, and whether local ablation can enhance systemic antitumor immunity remains unclear. In this retrospective study, we evaluated the efficacy of combining ablation with PD\u20101 inhibitor therapy versus PD\u20101 inhibitor monotherapy in patients with liver metastases. A total of 1337 patients who received PD\u20101 inhibitors with or without ablation between January 2017 and September 2022 at three institutions were reviewed. After propensity score matching, 234 patients were included, with 117 in the combination group and 117 in the monotherapy group. The combination group achieved significantly longer median overall survival (20.13 vs. 13.83\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.023) and progression\u2010free survival (12.73 vs. 5.20\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001). Progression of extrahepatic lesions was markedly lower in the combination group than in the monotherapy group (35.9% vs. 66.7%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001). Treatment\u2010related adverse events were common in both groups, with a higher frequency of grade 1\u20132 events such as transaminase elevation, fever, nausea, vomiting, and abdominal pain in the combination group, while the incidence of grade 3\u20134 toxicities was comparable between groups and no treatment\u2010related deaths occurred. Multivariate Cox regression confirmed treatment modality as an independent prognostic factor for survival (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001). These findings suggest that ablation of intrahepatic lesions may alleviate systemic immunosuppression and augment the efficacy of immunotherapy. The combination of ablation and PD\u20101 inhibitors represents a promising therapeutic approach for patients with liver metastases.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70462","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T04:20:33Z","timestamp":1774498833000},"page":"951-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liver metastasis ablation combined with\n                    <scp>PD<\/scp>\n                    \u20101 inhibitors improves immunotherapy efficacy: A multicenter cohort study"],"prefix":"10.1002","volume":"159","author":[{"given":"Dengyao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Minimally Invasive Intervention, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Department of Interventional Radiology, Xinjiang Key Laboratory of Translational Biomedical Engineering Research Tumor Hospital Affiliated to Xinjiang Medical University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingchen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Intervention, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongcun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Intervention, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanguo","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Xinjiang Key Laboratory of Translational Biomedical Engineering Research Tumor Hospital Affiliated to Xinjiang Medical University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Intervention, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dechao","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7978-5992","authenticated-orcid":false,"given":"Fujun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Intervention, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6750-8883","authenticated-orcid":false,"given":"Letao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Minimally Invasive Intervention, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0325"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6073-7"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aba0759"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1131-x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0337"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.6-1-14"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132958"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4011-8"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1352"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001268"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.09.026"},{"issue":"5","key":"e_1_2_12_13_1","first-page":"317","article-title":"Complications 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