{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:49:13Z","timestamp":1783453753401,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["2013\u2010143"],"award-info":[{"award-number":["2013\u2010143"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["ENV201306\/CLB"],"award-info":[{"award-number":["ENV201306\/CLB"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["AAPPVN2021.LCC\/BF"],"award-info":[{"award-number":["AAPPVN2021.LCC\/BF"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Early life exposure to pesticides, in particular through pesticides drift in residents nearby agricultural crops, is suspected to increase testicular germ cell tumors (TGCT) risk. We conducted a hospital\u2010based case\u2013control study of 472 TGCT cases and 683 matched controls aged 18\u201345\u2009years in France and estimated adult TGCT risk associated with agricultural surfaces around residence as a surrogate for environmental exposure to agricultural pesticides at time of birth. Surface of arable lands, orchards and vineyards in 500\u2009m buffer around the participants\u2019 residential address at birth was assessed using geographic information system (GIS) methods and software semi\u2010automatic processing of historical aerial images. Odds ratios (OR) for TGCT (overall and by histological subtype) and 95% confidence intervals (CI) were estimated using conditional logistic regression. No increased risk of TGCT was observed for presence of arable lands (OR\u2009=\u20091.14, CI\u2009=\u20090.86\u20131.52), vineyards (OR\u2009=\u20090.88, CI\u2009=\u20090.56\u20131.36) and agricultural surfaces overall (OR\u2009=\u20091.13, CI\u2009=\u20090.84\u20131.51) in 500\u2009m buffer around residence at birth. Presence of orchards (prevalence: 8.7%) was associated with a modest increase in TGCT risk (OR\u2009=\u20091.51, 95% CI\u2009=\u20090.99\u20132.32), slightly stronger for seminoma (OR\u2009=\u20091.78, 1.07\u20132.97) and in participants conceived or in their first trimester after conception during spring\u2013summer (OR\u2009=\u20091.70, 1.03\u20132.82). In conclusion, the study found no overall association between adult TGCT risk and agricultural crops around residence at birth, except for the presence of orchards, with a possible increase in seminoma risks, as well as TGCT risk in participants for whom the first trimester after conception fell into spring\u2013summer.<\/jats:p>","DOI":"10.1002\/ijc.70469","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:57:14Z","timestamp":1779170234000},"page":"1153-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Residence Near Agricultural Crops at Birth and Risk of Adult Testicular Germ Cell Tumors: A French Nationwide Case\u2013Control Study Using Historical Aerial\n                    <scp>GIS<\/scp>\n                    Data"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6958-0109","authenticated-orcid":false,"given":"Aur\u00e9lie M. N.","family":"Danjou","sequence":"first","affiliation":[{"name":"Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer\/World Health Organization  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2726-1000","authenticated-orcid":false,"given":"Astrid","family":"Coste","sequence":"additional","affiliation":[{"name":"Departement Pr\u00e9vention, Cancer et Environnement Centre L\u00e9on B\u00e9rard  Lyon France"},{"name":"Inserm U1296 Radiation: Defense, Health, Environment  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1774-2073","authenticated-orcid":false,"given":"L\u00e9ny","family":"Grassot","sequence":"additional","affiliation":[{"name":"Departement Pr\u00e9vention, Cancer et Environnement Centre L\u00e9on B\u00e9rard  Lyon France"},{"name":"Inserm U1296 Radiation: Defense, Health, Environment  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3321-6679","authenticated-orcid":false,"given":"Elodie","family":"Faure","sequence":"additional","affiliation":[{"name":"University Paris\u2010Saclay, UVSQ, Inserm, Gustave Roussy, \u201cExposome and Heredity\u201d Team, CESP UMR1018  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5577-5335","authenticated-orcid":false,"given":"Carlos","family":"Crispim\u2010Junior","sequence":"additional","affiliation":[{"name":"Univ Lyon 2, CNRS, INSA Lyon, UCBL, Centrale Lyon, LIRIS  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9208-6275","authenticated-orcid":false,"given":"Laure","family":"Tougne Rodet","sequence":"additional","affiliation":[{"name":"Univ Lyon 2, CNRS, INSA Lyon, UCBL, Centrale Lyon, LIRIS  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7543-7050","authenticated-orcid":false,"given":"Olivia","family":"P\u00e9rol","sequence":"additional","affiliation":[{"name":"Departement Pr\u00e9vention, Cancer et Environnement Centre L\u00e9on B\u00e9rard  Lyon France"},{"name":"Inserm U1296 Radiation: Defense, Health, Environment  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6608-8020","authenticated-orcid":false,"given":"R\u00e9mi","family":"B\u00e9ranger","sequence":"additional","affiliation":[{"name":"Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Sant\u00e9, Environnement et Travail), UMR_S 1085  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8198-4886","authenticated-orcid":false,"given":"Jeanne","family":"Perrin","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration Fran\u00e7aise des CECOS  Paris France"},{"name":"CNRS, IRD, IMBE Avignon University, Aix Marseille University  Marseille France"},{"name":"Centre Clinico\u2010Biologique d\u2019AMP\u2010CECOS AP\u2010HM La Conception University Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8805-6225","authenticated-orcid":false,"given":"Barbara","family":"Charbotel","sequence":"additional","affiliation":[{"name":"UMRESTTE, UMR T 9405, Ifsttar, Lyon 1 University, Lyon University, Eiffel University  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9687-2134","authenticated-orcid":false,"given":"Joachim","family":"Sch\u00fcz","sequence":"additional","affiliation":[{"name":"Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer\/World Health Organization  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3498-6499","authenticated-orcid":false,"given":"B\u00e9atrice","family":"Fervers","sequence":"additional","affiliation":[{"name":"Departement Pr\u00e9vention, Cancer et Environnement Centre L\u00e9on B\u00e9rard  Lyon France"},{"name":"Inserm U1296 Radiation: Defense, Health, Environment  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the TESTIS study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33999"},{"key":"e_1_2_14_4_1","first-page":"372","volume-title":"National Estimates of Cancer Incidence and Mortality in Metropolitan France Between 1990 and 2018. Volume 1\u2014Solid Tumors","author":"Defossez G.","year":"2019"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.11.035"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.02.029"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2015"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.5.972"},{"key":"e_1_2_14_9_1","volume-title":"Endotext","author":"Rajpert\u2010De Meyts E.","year":"2018"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34241"},{"key":"e_1_2_14_11_1","volume-title":"Construction D\u2019une Cartographie \u00e0 \u00c9chelle Fine Des Cultures Agricoles Pour Le Territoire Fran\u00e7ais M\u00e9tropolitain. Principes G\u00e9n\u00e9raux et M\u00e9thode","author":"Sant\u00e9 Publique France","year":"2022"},{"key":"e_1_2_14_12_1","first-page":"30","volume-title":"Apports de Produits Phytopharmaceutiques en Arobriculture: Nombre de Traitements et Indicateurs de Fr\u00e9quence de Traitements. Campagnes Agricoles 2015 et 2012","author":"Cretin L.","year":"2018"},{"key":"e_1_2_14_13_1","unstructured":"H.Ritchie M.Roser andP.Rosado \u201cPesticides \u201d2022 https:\/\/ourworldindata.org\/pesticides."},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab523"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2021.113881"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105210"},{"key":"e_1_2_14_17_1","volume-title":"Effects of Pesticides on Health: New Data","author":"INSERM","year":"2022"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8770"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12940\u2010021\u201000795\u2010y"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed\u20102022\u2010108601"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1303998"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201014\u2010563"},{"key":"e_1_2_14_23_1","volume-title":"International Classification of Diseases for Oncology: ICD\u2010O, First Revision","author":"Fritz A. G.","year":"2013"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12940\u2010017\u20100217\u20105"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP426"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2014.902029"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1684\/ers.2023.1758"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1109\/TIP.2019.2896492"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008\u2010682X.148079"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010019\u201005313\u20109"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw036"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18052355"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249800"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed\u20102019\u2010105801"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420\u2010021\u201001810\u2010y"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.91204"},{"key":"e_1_2_14_37_1","volume-title":"Pesticide Use in U.S. Agriculture: 21 Selected Crops, 1960\u20102008","author":"Fernandez\u2010Cornejo J.","year":"2014"},{"key":"e_1_2_14_38_1","volume-title":"The Use of Plant Protection Products in the European Union, Data 1992\u20132003","author":"Eurostat","year":"2007"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233718778397"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.5937\/arhfarm71\u201034359"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13978"},{"issue":"2","key":"e_1_2_14_42_1","first-page":"127","article-title":"Carcinogenicity of Captan","volume":"9","author":"Reuber M. D.","year":"1989","journal-title":"Journal of Environmental Pathology, Toxicology and Oncology"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4067"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010022\u201003136\u20102"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.153017"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12326"},{"key":"e_1_2_14_47_1","unstructured":"Commissariat G\u00e9n\u00e9ral au D\u00e9veloppement Durable \u201cL\u2019agriculture Biologique en France. Notre\u2010Environnement \u201d2023 http:\/\/www.notre\u2010environnement.gouv.fr\/themes\/economie\/l\u2010agriculture\u2010ressources\/article\/l\u2010agriculture\u2010biologique\u2010en\u2010france."},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18073477"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41370\u2010022\u201000467\u20100"},{"key":"e_1_2_14_50_1","unstructured":"US EPA \u201cPesticide Science and Assessing Pesticide Risks \u201d2025 Models for Pesticide Risk Assessment https:\/\/www.epa.gov\/pesticide\u2010science\u2010and\u2010assessing\u2010pesticide\u2010risks\/models\u2010pesticide\u2010risk\u2010assessment."},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1684\/bdc.2014.1901"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70469","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:36:20Z","timestamp":1783449380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1002\/ijc.70469"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70469","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"2025-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}